1993
Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells.
Bradley JR, Johnson DR, Pober JS. Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells. The Journal Of Immunology 1993, 150: 5544-55. PMID: 8390537, DOI: 10.4049/jimmunol.150.12.5544.Peer-Reviewed Original ResearchConceptsIFN-gamma-mediated inductionELAM-1Human endothelial cellsEndothelial cellsMHC moleculesReceptor-mediated endocytosisCytokine-inducible moleculesAnti-inflammatory therapyIL-1-induced increaseClass II MHC moleculesICAM-1 expressionClass I MHC moleculesVCAM-1 expressionCultured human endothelial cellsII MHC moleculesI MHC moleculesNew potential targetsICAM-1VCAM-1Levels of mRNADensity lipoproteinExposure of cellsTNFGene expressionTNF induction
1992
Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine‐rich C‐kinase substrate in human umbilical vein endothelial cells: Evidence for distinct patterns of protein kinase activation
Jacobson B, Pober J, Fenton J, Ewenstein B. Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine‐rich C‐kinase substrate in human umbilical vein endothelial cells: Evidence for distinct patterns of protein kinase activation. Journal Of Cellular Physiology 1992, 152: 166-176. PMID: 1320036, DOI: 10.1002/jcp.1041520121.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedDose-Response Relationship, DrugElectrophoresis, Polyacrylamide GelEndothelium, VascularEnzyme ActivationHistamineHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMolecular WeightMyristoylated Alanine-Rich C Kinase SubstratePhosphorylationPrecipitin TestsProtein KinasesProteinsReceptors, Cell SurfaceThrombin
1991
Tumor necrosis factor regulation of major histocompatibility complex gene expression
Johnson D, Pober J. Tumor necrosis factor regulation of major histocompatibility complex gene expression. Immunologic Research 1991, 10: 141. PMID: 1655923, DOI: 10.1007/bf02918161.Peer-Reviewed Original ResearchAnimalsBase SequenceGene Expression RegulationHumansMajor Histocompatibility ComplexMiceMolecular Sequence DataOncogenesReceptors, Cell SurfaceReceptors, Tumor Necrosis FactorRNA Processing, Post-TranscriptionalSecond Messenger SystemsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticTumor Necrosis Factor-alpha
1990
Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.
Johnson DR, Pober JS. Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 5183-5187. PMID: 2164225, PMCID: PMC54286, DOI: 10.1073/pnas.87.13.5183.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCell NucleusCells, CulturedDrug SynergismEndothelium, VascularFlow CytometryGenes, MHC Class IHistocompatibility Antigens Class IHumansInterferon Type IInterferon-gammaMacromolecular SubstancesMolecular Sequence DataReceptors, Cell SurfaceReceptors, Tumor Necrosis FactorRecombinant ProteinsRNA, MessengerSequence Homology, Nucleic AcidTranscription, GeneticTumor Necrosis Factor-alphaConceptsNecrosis factorHuman endothelial cellsEndothelial cellsClass IInterferon gammaImmune interferonMRNA levelsMajor histocompatibility complex moleculesTumor necrosis factorHLA class IClass I major histocompatibility complex moleculesCultured human endothelial cellsHistocompatibility complex moleculesUntreated endothelial cellsSynergistic increase
1987
Identification of an inducible endothelial-leukocyte adhesion molecule.
Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA. Identification of an inducible endothelial-leukocyte adhesion molecule. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 9238-9242. PMID: 2827173, PMCID: PMC299728, DOI: 10.1073/pnas.84.24.9238.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsCell surface proteinsEndothelial cell surface proteinsUnstimulated human endothelial cellsCell surface structuresHL-60 cellsSame polypeptideHL-60 adhesionCultured human endothelial cellsAdhesion assaysAdhesive interactionsH18/7Adhesion moleculesCytokine-stimulated human endothelial cellsDependent fashionCell surface antigensEndothelial cellsEndothelial leukocyte adhesion moleculeEndothelial leukocyte adhesion molecule-1AdhesionCellsAdhesion molecule-1Monoclonal antibodiesSites of inflammationLesser extent