1986
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone MA. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 4533-4537. PMID: 3487091, PMCID: PMC323768, DOI: 10.1073/pnas.83.12.4533.Peer-Reviewed Original ResearchConceptsRecombinant tumor necrosis factorCultured human vascular endotheliumTumor necrosis factorIL-1Procoagulant activityHuman vascular endotheliumNecrosis factorInterleukin-1Vascular endotheliumTissue factor-like procoagulant activityInduction of PCANatural human interleukin-1Human recombinant tumor necrosis factorEndothelial cell damageCellular procoagulant activityEndothelial procoagulant activityRecombinant IL-1Specific neutralizing antiseraHuman interleukin-1Effects of TNFInitiation of coagulationIliac arteryMaximal dosesPCA responseSaphenous vein
1985
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. American Journal Of Pathology 1985, 121: 394-403. PMID: 3878084, PMCID: PMC1887931.Peer-Reviewed Original ResearchConceptsInterleukin-1Procoagulant activityHuman endothelial cellsEndothelial cellsVascular endotheliumTissue factor-like procoagulant activityLeukocyte adhesionPeripheral blood polymorphonuclear leukocytesHuman peripheral blood polymorphonuclear leukocytesCultured human vascular endothelial cellsBlood polymorphonuclear leukocytesIL-1 actionIL-1 effectsRecombinant IL-1Sites of inflammationHuman vascular endothelial cellsInterleukin-1 activationVascular endothelial cellsEnhanced leukocyteIntravascular coagulationImmune mediatorsIL-2Saphenous veinEndothelial cell surfaceUmbilical vein