Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigensImmune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.
Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA, Strominger JL, Pober JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 4917-4921. PMID: 6431411, PMCID: PMC391603, DOI: 10.1073/pnas.81.15.4917.Peer-Reviewed Original ResearchConceptsAntigen expressionIFN-gammaSurface expressionClass II major histocompatibility complex antigensClass II antigen expressionImmune interferonClass II MHC antigensEndothelial cellsMajor histocompatibility complex antigensImmune accessory functionHLA-DR antigensClass II antigensHistocompatibility complex antigensVascular endothelial cellsHLA-DCDermal fibroblastsHuman endothelial cellsHLA-DRMHC antigensII antigensComplex antigensB antigensDe novo appearanceClass IIStromal cells