1997
Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor.
Mach F, Schönbeck U, Bonnefoy J, Pober J, Libby P. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation 1997, 96: 396-9. PMID: 9244201, DOI: 10.1161/01.cir.96.2.396.Peer-Reviewed Original ResearchConceptsLigation of CD40Tissue factorMacrophage functionMonocyte/macrophage functionAcute coronary eventsAcute coronary syndromeAnti-CD40L antibodyHuman monocytes/macrophagesCytokine interleukin-1Mononuclear phagocyte functionMonocytes/macrophagesInduction of collagenaseActivated T cellsCoronary eventsCoronary syndromeMatrix-degrading proteinasesClinical manifestationsPlaque disruptionTumor necrosisT cell membranePlaque ruptureT cellsInterleukin-1Phagocyte functionReceptor CD40
1986
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.
Leung DY, Geha RS, Newburger JW, Burns JC, Fiers W, Lapierre LA, Pober JS. Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. Journal Of Experimental Medicine 1986, 164: 1958-1972. PMID: 3491174, PMCID: PMC2188474, DOI: 10.1084/jem.164.6.1958.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeTumor necrosis factorKawasaki syndromeHuman endothelial cellsIL-1Cytotoxic antibodiesImmune activationEndothelial cellsNecrosis factorTarget antigenComplement-dependent cytotoxic activityAcute febrile illnessEndothelial cell antigensVascular smooth muscle cellsAge-matched controlsMonocytes/macrophagesSmooth muscle cellsCultured vascular endothelial cellsVascular endothelial cellsComplement-mediated killingDiffuse vasculitisConvalescent phaseFebrile illnessAcute phaseVascular injury