1995
Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules.
Bradley JR, Thiru S, Pober JS. Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules. American Journal Of Pathology 1995, 147: 627-41. PMID: 7677177, PMCID: PMC1870992.Peer-Reviewed Original ResearchConceptsMembrane protein distributionFocal adhesion plaquesAdjacent cellsNormal spatial organizationNew protein synthesisEndothelial cellsSurface protein expressionBeta 3 integrinActin organizationDendrite-like processesCell peripheryEndothelial retractionCell adhesion moleculeHuman umbilical vein endothelial cellsAdhesion plaquesUmbilical vein endothelial cellsCellular metabolismActin filamentsProtein distributionProtein synthesisVein endothelial cellsNormal endothelial cell functionEndothelial cell functionApical capCell retraction
1993
Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.
Bradley JR, Johnson DR, Pober JS. Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. American Journal Of Pathology 1993, 142: 1598-609. PMID: 8098585, PMCID: PMC1886909.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Tumor necrosis factorAdhesion molecule-1Major histocompatibility complex class I.Major histocompatibility complex class IHistocompatibility complex class IMolecule-1Complex class IInterleukin-1Intercellular adhesion molecule-1 surface expressionMumol/L hydrogen peroxideVascular cell adhesion molecule-1Transcription factor nuclear factor kappa BEndothelial leukocyte adhesion molecule-1Class ICell adhesion molecule-1Leukocyte-derived cytokinesNuclear factor kappa BVascular endothelial cell functionLeukocyte adhesion molecule-1Surface expressionClass I.Factor kappa BEC surface receptorsEndothelial cell function
1988
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Pober JS. Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology. American Journal Of Pathology 1988, 133: 426-33. PMID: 2462353, PMCID: PMC1880803.Peer-Reviewed Original ResearchConceptsEndothelial cell activationCell activationMolecular biologic techniquesEndothelial cell functionClinical studiesMorphologic definitionVascular endotheliumBiologic techniquesPatient-based clinical researchClinical researchBiologic definitionVivo studiesHarmful sequencesCell functionDysfunctionInjuryActivationRecent studies
1986
Induction and detection of a human endothelial activation antigen in vivo.
Cotran RS, Gimbrone MA, Bevilacqua MP, Mendrick DL, Pober JS. Induction and detection of a human endothelial activation antigen in vivo. Journal Of Experimental Medicine 1986, 164: 661-666. PMID: 3723080, PMCID: PMC2188244, DOI: 10.1084/jem.164.2.661.Peer-Reviewed Original ResearchConceptsEndothelial activation antigenActivation antigensSequential skin biopsiesStrong positive stainingHuman umbilical vein endothelial cell culturesEndothelial cell functionLymph nodesHypersensitivity reactionsSkin biopsiesInflammatory reactionImmunoperoxidase techniqueVascular endotheliumPositive stainingEndothelial cell culturesNormal endotheliumMurine mAbsUseful markerH4/18EndotheliumAntigenCell functionSkinPathological tissuesHuman skinTissue