2022
Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes
Manes TD, Wang V, Pober JS. Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes. Frontiers In Immunology 2022, 13: 1016361. PMID: 36275645, PMCID: PMC9582530, DOI: 10.3389/fimmu.2022.1016361.Peer-Reviewed Original ResearchConceptsT effector cellsT cellsTransendothelial migrationEndothelial cellsCheckpoint inhibitorsEffector cellsCytokine productionCytokine synthesisPeripheral blood T cell subpopulationsEffector memory T cellsEngagement of OX40Presentation of superantigensRegulatory T cellsMemory T cellsT cell subpopulationsT-cell typeT cell CD28Antigen-independent signalT cell activationT cell receptorHuman dermal microvascularCD8 effectorsT-regsHuman endothelial cellsActivated CD4
1998
Human endothelial cells effectively costimulate cytokine production by, but not differentiation of, naive CD4+ T cells.
Ma W, Pober J. Human endothelial cells effectively costimulate cytokine production by, but not differentiation of, naive CD4+ T cells. The Journal Of Immunology 1998, 161: 2158-67. PMID: 9725207, DOI: 10.4049/jimmunol.161.5.2158.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdultCD4-Positive T-LymphocytesCD58 AntigensCell AdhesionCell DifferentiationCells, CulturedCytokinesEndothelium, VascularHumansImmunologic MemoryInterferon-gammaInterleukin-12Interleukin-2Interleukin-4InterphaseLeukocytes, MononuclearLymphocyte ActivationT-Lymphocyte SubsetsTh1 CellsUmbilical VeinsConceptsPeripheral blood adherent mononuclear cellsExogenous IL-12Naive T cellsT cellsIL-12Endothelial cellsMemory CD4Human endothelial cellsCytokine productionNaive CD4B7 moleculesIL-2IFN-gammaBone marrow-derived APCsBlood adherent mononuclear cellsB7 molecule expressionIL-12 supplementationIntracellular cytokine stainingTh1-like cellsIL-4 productionIFN-gamma productionCytokine stainingMononuclear cellsIL-4Molecule expression