2014
Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
Manes TD, Pober JS. Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells. The Journal Of Immunology 2014, 193: 5809-5815. PMID: 25367116, PMCID: PMC4258477, DOI: 10.4049/jimmunol.1401665.Peer-Reviewed Original ResearchConceptsEffector memory CD4 T cellsMemory CD4 T cellsCD4 T cellsT cellsTransendothelial migrationImmune synapse formationEndothelial cell monolayersInflammatory chemokinesMorphologic manifestationsGranzyme releaseSynapse formationTCR recognitionGranule dischargeDynein-driven transportChemokinesCell monolayersEarly eventsEndotheliumCytosolic granulesCellsMTOC reorientationProteolytic activityMicrotubule organizing centerMolecular requirementsGranule function
1984
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.
Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone MA. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. Journal Of Experimental Medicine 1984, 160: 618-623. PMID: 6332168, PMCID: PMC2187463, DOI: 10.1084/jem.160.2.618.Peer-Reviewed Original ResearchConceptsEndothelial cell procoagulant activityCell procoagulant activityProcoagulant activityInterleukin-1Cultured human vascular endotheliumHuman monocyte-derived interleukin 1Coagulation factor-deficient plasmasMonocyte-derived interleukin 1Human vascular endothelial cellsHuman vascular endotheliumVascular endothelial cellsFactor-deficient plasmaIL-1 inductionIntravascular coagulationInflammatory conditionsCell surface expressionIntact cell monolayersVascular endotheliumEndothelial cellsPotent inducerSurface expressionCell monolayersProtein synthesisPathogenesisActivity