2011
Role of semaphorin 7a signaling in transforming growth factor β1–induced lung fibrosis and scleroderma‐related interstitial lung disease
Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1–induced lung fibrosis and scleroderma‐related interstitial lung disease. Arthritis & Rheumatism 2011, 63: 2484-2494. PMID: 21484765, PMCID: PMC3651701, DOI: 10.1002/art.30386.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsInterstitial lung diseaseBone marrow-derived cellsMarrow-derived cellsSemaphorin 7AGrowth factor-β1Lung diseaseLung fibrosisFactor-β1Human peripheral blood mononuclear cellsNormal human peripheral blood mononuclear cellsSemaphorin 7a expressionBone marrow transplantationBlood mononuclear cellsReceptor β1 integrinΒ1 integrinFibrocyte differentiationMarrow transplantationPulmonary fibrosisMononuclear cellsProfibrotic effectsTGFβ1 geneMurine modelFibrosisTissue accumulation
2007
VEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo
Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF‐induced heme oxygenase‐1 confers cytoprotection from lethal hyperoxia in vivo. The FASEB Journal 2007, 21: 1422-1432. PMID: 17264168, DOI: 10.1096/fj.06-6661com.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBronchoalveolar Lavage FluidCytoprotectionDisease Models, AnimalDNA PrimersEnzyme InductionHeme Oxygenase (Decyclizing)HumansHyperoxiaIn Situ Nick-End LabelingLipid PeroxidationLungMiceMice, TransgenicRespiratory Distress SyndromeReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingVascular Endothelial Growth Factor AConceptsHyperoxic acute lung injuryVascular endothelial growth factorAcute lung injuryHeme oxygenase-1Lung injuryTransgenic miceVivo modelLung lavage protein concentrationVEGF transgenic miceLavage protein concentrationEndothelial growth factorHO-1 mRNAHO-1 functionEffect of inhibitionShort hairpin RNAProlong survivalDry ratioProtective effectLethal hyperoxiaHyperoxia resultsOxygenase-1Mouse lungTUNEL stainingCytoprotective effectsInjury