A tale of two ligands: angiopoietins, the endothelium, and outcomes
Siner JM. A tale of two ligands: angiopoietins, the endothelium, and outcomes. Critical Care 2013, 17: 1007. PMID: 24131798, PMCID: PMC4057381, DOI: 10.1186/cc13066.Commentaries, Editorials and LettersConceptsAng-2/AngAng-2 levelsTie-2 receptorSeptic shockAng-1Elevated Ang-2 levelsCompetitive partial agonistInitial feverFebrile neutropeniaEndothelial dysfunctionAng-2Prognostic informationAngiopoietin-2Critical careSepsisEarly markerPartial agonistAngiopoietin-1Growth factorEarly clueAngiopoietinsVascular stabilityOutcomesDetectable alterationsAgonists