2013
A tale of two ligands: angiopoietins, the endothelium, and outcomes
Siner JM. A tale of two ligands: angiopoietins, the endothelium, and outcomes. Critical Care 2013, 17: 1007. PMID: 24131798, PMCID: PMC4057381, DOI: 10.1186/cc13066.Commentaries, Editorials and LettersConceptsAng-2/AngAng-2 levelsTie-2 receptorSeptic shockAng-1Elevated Ang-2 levelsCompetitive partial agonistInitial feverFebrile neutropeniaEndothelial dysfunctionAng-2Prognostic informationAngiopoietin-2Critical careSepsisEarly markerPartial agonistAngiopoietin-1Growth factorEarly clueAngiopoietinsVascular stabilityOutcomesDetectable alterationsAgonists
2009
ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS
Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS. Shock 2009, 31: 348-353. PMID: 18791490, DOI: 10.1097/shk.0b013e318188bd06.Peer-Reviewed Original ResearchConceptsAng-2 levelsIntensive care unitAng-2Tertiary care medical intensive care unitProspective observational cohort studySerum Ang-2 levelsSerum angiopoietin-2 levelsMedical intensive care unitSerum Ang-2Observational cohort studyAngiopoietin-2 levelsIL-6 levelsHospital mortalityHuman sepsisICU admissionSevere sepsisCohort studyEndothelial dysfunctionHospital dischargeICU patientsIllness scoresSeptic shockCare unitIL-6Increased Mortality