2017
Sarcoidosis: Drugs under Investigation
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Sarcoidosis: Drugs under Investigation. Seminars In Respiratory And Critical Care Medicine 2017, 38: 532-537. PMID: 28750466, DOI: 10.1055/s-0037-1603768.Commentaries, Editorials and Letters
2016
Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose. Pneumologie 2016, 70: 231-240. PMID: 26937647, DOI: 10.1055/s-0041-108311.Commentaries, Editorials and LettersConceptsSarcoid patientsGranuloma formationSarcoidosis-associated fatigueClinical pharmacological studiesEtiology of sarcoidosisGenetics of sarcoidosisPulmonary hypertensionMycobacterial antigensAntigen presentationSarcoidosisPositive studiesClinical researchPatientsSubcohortAutoimmunityPositive outcomesNew studiesWide association studyAssociation studiesHypertensionAutoantigensPathomechanismEtiologyNew findingsStudy
2015
Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Schupp J, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg M, Prasse A. Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro. BMC Pulmonary Medicine 2015, 15: 75. PMID: 26204953, PMCID: PMC4513400, DOI: 10.1186/s12890-015-0070-7.Peer-Reviewed Original ResearchConceptsHeat-killed P. acnesSarcoid patientsP. acnesBAL cellsBAL fluidTotal IgGImmune responseHealthy volunteersPathogenesis of sarcoidosisSpecific antibodiesGM-CSF productionIgA titresIgA levelsLymph nodesInflammatory cytokinesGranuloma formationMore TNFSarcoidosisPatientsPropionibacterium acnesAcneGM-CSFElevated levelsAntibodiesIgG