2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskModelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentateβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cellsNanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration
Datta D, Perone I, Wijegunawardana D, Liang F, Morozov Y, Arellano J, Duque A, Xie Z, van Dyck C, Joyce M, Arnsten A. Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration. Alzheimer's & Dementia 2024, 20: 2843-2860. PMID: 38445818, PMCID: PMC11032534, DOI: 10.1002/alz.13737.Peer-Reviewed Original ResearchA coming-of-age story: adult neurogenesis or adolescent neurogenesis in rodents?
Arellano J, Duque A, Rakic P. A coming-of-age story: adult neurogenesis or adolescent neurogenesis in rodents? Frontiers In Neuroscience 2024, 18: 1383728. PMID: 38505771, PMCID: PMC10948509, DOI: 10.3389/fnins.2024.1383728.Peer-Reviewed Original ResearchAdult hippocampal neurogenesisHippocampal neurogenesisInter-strain differencesOnset of adulthoodAdult neurogenesisAdolescent periodJackson LabsPostnatal dayNeurogenesisAdulthoodDevelopment of miceMonths of ageAdolescentsPostnatal development of miceRatsRodentsPostnatal developmentAdultsOlder animalsComing-of-age storyMiceYounger agePerceived importanceInter-individualFunctional studies
2023
Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
Bathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseEntorhinal cortexGCPII inhibitionDorsolateral prefrontal cortexChronic inhibitionTau pathologyTau hyperphosphorylationAged macaquesType 3 metabotropic glutamate receptorAlzheimer's diseasePrefrontal cortexRhesus macaquesVehicle-treated monkeysAged rhesus macaquesMetabotropic glutamate receptorsApparent side effectsAmyloid beta 1Regulation of calciumGCPII inhibitorsKey etiological factorGCPII activityPrimate dlPFCNeuronal damageCSF analysisCalcium dysregulationLocalization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeuronsMolecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original ResearchOld Models Know Wrinkles Best
Arellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.Peer-Reviewed Original Research
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrusNeuroanatomical and psychological considerations in temporal lobe epilepsy
DeFelipe J, DeFelipe-Oroquieta J, Furcila D, Muñoz-Alegre M, Maestú F, Sola R, Blázquez-Llorca L, Armañanzas R, Kastanaskaute A, Alonso-Nanclares L, Rockland K, Arellano J. Neuroanatomical and psychological considerations in temporal lobe epilepsy. Frontiers In Neuroanatomy 2022, 16: 995286. PMID: 36590377, PMCID: PMC9794593, DOI: 10.3389/fnana.2022.995286.Peer-Reviewed Original ResearchTemporal lobe epilepsyBrain samplesLobe epilepsyEpileptic patientsBrain tissuePutative anatomical substratesTypes of patientsAbnormal brain functioningHippocampal sclerosisEpilepsy surgeryTLE patientsEpileptic tissuePsychopathological alterationsFocal epilepsyNormal histologyIndividual variabilityCritical patient informationMedical characteristicsPatientsAnatomical substratePost-surgical performancePsychological alterationsNeuropsychological evaluationEpilepsySubstantial individual variability
2019
P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD
Datta D, Morozov Y, Arellano J, van Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD. Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.Peer-Reviewed Original Research
2012
Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells
Sarkisian M, Arellano J, Breunig J. Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells. 2012, 105-129. DOI: 10.1007/978-94-007-5808-7_4.Peer-Reviewed Original ResearchCentral nervous systemPrimary ciliaCerebral cortexNeuronal ciliaCourse of evolutionPrimary neuronal ciliaPutative functionsPostnatal cerebral cortexNon-neuronal cellsMammalian cerebral cortexMaturation of cellsAbnormal ciliogenesisUnexpected roleCell typesCiliaCiliogenesisNervous systemPaucity of informationElectron microscopic studyCortexPattern of growthLack of methodsAvailable research toolsFurther investigationCells
2009
Development of the Primate Cerebral Cortex
Rakic P, Arellano J, Breunig J. Development of the Primate Cerebral Cortex. 2009 DOI: 10.7551/mitpress/8029.003.0005.Peer-Reviewed Original ResearchCognitive neuroscienceProblem of qualiaComplex cognitionEmotional brainMemory researchPsychological realityConscious experienceExperience shapeFourth EditionLanguage facultyNeuroscienceFuture eventsMotor systemPrimate cerebral cortexCognitionFundamental stanceCentral tenetNew ideasLongstanding theoryMethodological workClassic referencesThird editionBaseline activityEmpirical evidenceTheoretical attempts
2007
Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies
Arellano J, Benavides-Piccione R, DeFelipe J, Yuste R. Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies. Frontiers In Neuroscience 2007, 1: 131-143. PMID: 18982124, PMCID: PMC2518053, DOI: 10.3389/neuro.01.1.1.010.2007.Peer-Reviewed Original ResearchSpine head volumeDendritic spinesSynaptic strengthSpine morphologyLayer 2/3 pyramidal cellsPostsynaptic densityMouse visual cortexMost excitatory synapsesReady releasable poolPostsynaptic receptorsPyramidal cellsExcitatory synapsesHead volumeDistinguishable subtypesCortical circuitsGolgi impregnationVisual cortexParent dendriteSpine neckPSD areaSpineSynaptic featuresFunctional parametersNeck lengthNeck diameterQuantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
Andrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.Peer-Reviewed Original ResearchConceptsNeuronal lossProtein parvalbuminIntractable temporal lobe epilepsyCalcium binding protein parvalbuminParvalbumin-immunoreactive cellsTotal neuronal lossHippocampal neuronal lossParvalbumin-immunoreactive neuronsPV-ir neuronsHuman epileptic hippocampusMesial temporal structuresTemporal lobe epilepsyBinding protein parvalbuminTotal neuronal densityQuantitative stereological methodsAutopsy hippocampiAxonal reorganizationPV-irHippocampal sclerosisEpileptic hippocampusLobe epilepsyNeuronal densityInhibitory circuitsEpileptogenic processGABAergic interneuronsGlowing Green Pyramids: A False Positive for Neocortical Neurogenesis Reveals a Novel Neuronal–Microglial Fusion in the Postnatal Brain
Breunig J, Arellano J. Glowing Green Pyramids: A False Positive for Neocortical Neurogenesis Reveals a Novel Neuronal–Microglial Fusion in the Postnatal Brain. Journal Of Neuroscience 2007, 27: 1507-1508. PMID: 17304702, PMCID: PMC6673745, DOI: 10.1523/jneurosci.5475-06.2007.Peer-Reviewed Original Research4.12 Specializations of the Cortical Microstructure of Humans
DeFelipe J, Alonso-Nanclares L, Arellano J, Ballesteros-Yáñez I, Benavides-Piccione R, Muñoz A. 4.12 Specializations of the Cortical Microstructure of Humans. 2007, 167-190. DOI: 10.1016/b0-12-370878-8/00043-4.Peer-Reviewed Original ResearchHuman neocortexHuman cortical functionNeocortex of humansTypes of neuronsNumber of synapsesCerebral cortexGABAergic interneuronsCortical functionCortical areasCertain subtypesMicroanatomical studyNeocortexCortical microstructureNeocortical circuitsCortical organizationCortical structuresNeuronsInterneuronsCortexWide variationMammalian speciesLarger brainsHumansSynaptologyUnique specializations
2006
Non-synaptic dendritic spines in neocortex
Arellano J, Espinosa A, Fairén A, Yuste R, DeFelipe J. Non-synaptic dendritic spines in neocortex. Neuroscience 2006, 145: 464-469. PMID: 17240073, DOI: 10.1016/j.neuroscience.2006.12.015.Peer-Reviewed Original Research
2005
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Benavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.Peer-Reviewed Original ResearchConceptsHuman temporal cortexPyramidal cellsPyramidal neuronsCatecholaminergic innervationCatecholaminergic afferentsCatecholaminergic fibersTyrosine hydroxylaseTemporal cortexHuman neocortexBasal dendritic regionsBasal dendritic arborsHuman cortical organizationEnzyme tyrosine hydroxylaseHuman cortical tissueDendritic arborsExcitatory inputsCortical functionLayers IIHigher cognitive functionsLayers IIIaCognitive functionDendritic compartmentsCortical tissueCortical organizationLucifer Yellow