2023
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeurons
2002
Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices
Araque A, Martín E, Perea G, Arellano J, Buño W. Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices. Journal Of Neuroscience 2002, 22: 2443-2450. PMID: 11923408, PMCID: PMC6758296, DOI: 10.1523/jneurosci.22-07-02443.2002.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAstrocytesCalciumCholinergic FibersDiagonal Band of BrocaElectric StimulationGlutamic AcidHippocampusIn Vitro TechniquesIntracellular FluidNeurons, AfferentNeurotransmitter AgentsPatch-Clamp TechniquesRatsRats, WistarReceptors, GlutamateReceptors, MuscarinicSeptum of BrainSignal TransductionSynapsesConceptsAstrocytic responseIntracellular Ca2Stratum oriens/alveusHippocampal stratum oriensOriens/alveusMuscarinic cholinergic receptorsGlutamate receptor antagonistsGlutamate transporter activityWhole-cell membrane currentsDifferent brain areasLevels of astrocytesCholinergic receptorsHippocampal astrocytesMuscarinic receptorsCholinergic activityReceptor antagonistStratum oriensAcetylcholine actsCholinergic afferentsAxonal inputsHippocampal slicesDiagonal bandGlial cellsTransporter antagonistsBrain slices