2022
Neuroanatomical and psychological considerations in temporal lobe epilepsy
DeFelipe J, DeFelipe-Oroquieta J, Furcila D, Muñoz-Alegre M, Maestú F, Sola R, Blázquez-Llorca L, Armañanzas R, Kastanaskaute A, Alonso-Nanclares L, Rockland K, Arellano J. Neuroanatomical and psychological considerations in temporal lobe epilepsy. Frontiers In Neuroanatomy 2022, 16: 995286. PMID: 36590377, PMCID: PMC9794593, DOI: 10.3389/fnana.2022.995286.Peer-Reviewed Original ResearchTemporal lobe epilepsyBrain samplesLobe epilepsyEpileptic patientsBrain tissuePutative anatomical substratesTypes of patientsAbnormal brain functioningHippocampal sclerosisEpilepsy surgeryTLE patientsEpileptic tissuePsychopathological alterationsFocal epilepsyNormal histologyIndividual variabilityCritical patient informationMedical characteristicsPatientsAnatomical substratePost-surgical performancePsychological alterationsNeuropsychological evaluationEpilepsySubstantial individual variability
2007
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
Andrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.Peer-Reviewed Original ResearchConceptsNeuronal lossProtein parvalbuminIntractable temporal lobe epilepsyCalcium binding protein parvalbuminParvalbumin-immunoreactive cellsTotal neuronal lossHippocampal neuronal lossParvalbumin-immunoreactive neuronsPV-ir neuronsHuman epileptic hippocampusMesial temporal structuresTemporal lobe epilepsyBinding protein parvalbuminTotal neuronal densityQuantitative stereological methodsAutopsy hippocampiAxonal reorganizationPV-irHippocampal sclerosisEpileptic hippocampusLobe epilepsyNeuronal densityInhibitory circuitsEpileptogenic processGABAergic interneurons
2003
Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
Arellano J, Muñoz A, Ballesteros-Yáñez I, Sola R, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2003, 127: 45-64. PMID: 14534159, DOI: 10.1093/brain/awh004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCalbindinsCarrier ProteinsDentate GyrusEpilepsy, Temporal LobeFemaleGABA Plasma Membrane Transport ProteinsHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleMembrane ProteinsMembrane Transport ProteinsMiddle AgedNeural Cell Adhesion Molecule L1Organic Anion TransportersParvalbuminsPresynaptic TerminalsS100 Calcium Binding Protein GSialic AcidsTerminology as TopicConceptsCalbindin D-28kChandelier cellsDentate gyrusProtein parvalbuminHippocampal formationSclerotic hippocampusGABAergic circuitsNeuron lossPyramidal layerCalcium-binding protein parvalbuminBasket formationImpairment of GABANormal hippocampal formationHuman epileptic hippocampusTemporal lobe epilepsyCortical pyramidal cellsAxon initial segmentNeural cell adhesion moleculeGABA transporter 1PV-immunoreactiveHippocampal sclerosisClinical characteristicsEpileptic hippocampusLobe epilepsyDifferent hippocampal fields
2002
GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy
Muñoz A, Arellano J, Defelipe J. GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy. The Journal Of Comparative Neurology 2002, 449: 166-179. PMID: 12115687, DOI: 10.1002/cne.10287.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman hippocampal formationLayer VHippocampal formationLobe epilepsyB immunoreactivityDentate gyrusPyramidal cellsEpileptic patientsPerirhinal cortexProtein expressionInhibitory synaptic transmissionLarge pyramidal cellsMesial temporal cortexPolymorphic cell layerDeep layer VReceptor protein expressionGranule cell layerCell layerAdjacent cortical structuresB protein expressionHippocampal sclerosisNeuronal lossApical dendritesAmmon's hornThe neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity.
DeFelipe Oroquieta J, Arellano J, Alonso L, Muñoz A. The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity. Revista De Neurologia 2002, 34: 401-8. PMID: 12040509, DOI: 10.33588/rn.3405.2001403.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyPrimary epileptogenic regionEpileptogenic regionEpileptic activitySynaptic reorganizationLobe epilepsySpecific anatomical connectionsMesial sclerosisNeuronal lossPerilesional areaCommon pathologyInitial lesionCortical circuitsHippocampal formationNeuronal circuitsAnatomical connectionsCortical tissueSecondary changesEpilepsySimilar changesLesionsGliosisEpileptogenicitySclerosisPatients
2001
Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome
DeFelipe J, Segura T, Arellano J, Merchán A, DeFelipe‐Oroquieta J, Martín P, Maestú F, Cajal S, Sánchez A, Sola R. Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome. Epilepsia 2001, 42: 1198-1203. PMID: 11580770, DOI: 10.1046/j.1528-1157.2001.45800.x.Peer-Reviewed Original ResearchConceptsParry-Romberg syndromeSeizure activityDentate gyrusIntractable temporal lobe epilepsyComplete seizure reliefPolymorph cell layerTemporal lobe epilepsyCause of epilepsyDentate gyrus circuitryNumber of synapsesStandard histopathologic methodsGamma-aminobutyric acidInhibitory basket cellsCell-sparse regionNeuropathologic findingsNeuropathological findingsSeizure reliefAxosomatic synapsesLobe epilepsySurgical interventionElectron microscopic levelMesial structuresEctopic massBasket cellsEntorhinal cortex