2004
CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy
Velez‐Pardo C, Arellano J, Cardona‐Gomez P, Del Rio M, Lopera F, De Felipe J. CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy. Epilepsia 2004, 45: 751-756. PMID: 15230697, DOI: 10.1111/j.0013-9580.2004.55403.x.Peer-Reviewed Original ResearchConceptsHippocampal neuronal lossNeuronal lossCA1 fieldAlzheimer's diseaseFAD patientsEpileptic seizuresPresenilin-1 E280A mutationMesial temporal lobe structuresAppearance of epilepsyCA1 hippocampal regionNeuronal cell lossSubpopulation of patientsFamilial AD patientsTemporal lobe structuresPresenilin 1 mutationNeuronal depopulationHippocampal sclerosisAD pathologyAD patientsNeurofibrillary tanglesEpilepsy patientsHippocampal regionHippocampal formationPatientsCoronal sections
2003
Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
Arellano J, Muñoz A, Ballesteros-Yáñez I, Sola R, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2003, 127: 45-64. PMID: 14534159, DOI: 10.1093/brain/awh004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCalbindinsCarrier ProteinsDentate GyrusEpilepsy, Temporal LobeFemaleGABA Plasma Membrane Transport ProteinsHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleMembrane ProteinsMembrane Transport ProteinsMiddle AgedNeural Cell Adhesion Molecule L1Organic Anion TransportersParvalbuminsPresynaptic TerminalsS100 Calcium Binding Protein GSialic AcidsTerminology as TopicConceptsCalbindin D-28kChandelier cellsDentate gyrusProtein parvalbuminHippocampal formationSclerotic hippocampusGABAergic circuitsNeuron lossPyramidal layerCalcium-binding protein parvalbuminBasket formationImpairment of GABANormal hippocampal formationHuman epileptic hippocampusTemporal lobe epilepsyCortical pyramidal cellsAxon initial segmentNeural cell adhesion moleculeGABA transporter 1PV-immunoreactiveHippocampal sclerosisClinical characteristicsEpileptic hippocampusLobe epilepsyDifferent hippocampal fields
2002
GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy
Muñoz A, Arellano J, Defelipe J. GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy. The Journal Of Comparative Neurology 2002, 449: 166-179. PMID: 12115687, DOI: 10.1002/cne.10287.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman hippocampal formationLayer VHippocampal formationLobe epilepsyB immunoreactivityDentate gyrusPyramidal cellsEpileptic patientsPerirhinal cortexProtein expressionInhibitory synaptic transmissionLarge pyramidal cellsMesial temporal cortexPolymorphic cell layerDeep layer VReceptor protein expressionGranule cell layerCell layerAdjacent cortical structuresB protein expressionHippocampal sclerosisNeuronal lossApical dendritesAmmon's hornThe neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity.
DeFelipe Oroquieta J, Arellano J, Alonso L, Muñoz A. The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity. Revista De Neurologia 2002, 34: 401-8. PMID: 12040509, DOI: 10.33588/rn.3405.2001403.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyPrimary epileptogenic regionEpileptogenic regionEpileptic activitySynaptic reorganizationLobe epilepsySpecific anatomical connectionsMesial sclerosisNeuronal lossPerilesional areaCommon pathologyInitial lesionCortical circuitsHippocampal formationNeuronal circuitsAnatomical connectionsCortical tissueSecondary changesEpilepsySimilar changesLesionsGliosisEpileptogenicitySclerosisPatients