Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome
DeFelipe J, Segura T, Arellano J, Merchán A, DeFelipe‐Oroquieta J, Martín P, Maestú F, Cajal S, Sánchez A, Sola R. Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome. Epilepsia 2001, 42: 1198-1203. PMID: 11580770, DOI: 10.1046/j.1528-1157.2001.45800.x.Peer-Reviewed Original ResearchConceptsParry-Romberg syndromeSeizure activityDentate gyrusIntractable temporal lobe epilepsyComplete seizure reliefPolymorph cell layerTemporal lobe epilepsyCause of epilepsyDentate gyrus circuitryNumber of synapsesStandard histopathologic methodsGamma-aminobutyric acidInhibitory basket cellsCell-sparse regionNeuropathologic findingsNeuropathological findingsSeizure reliefAxosomatic synapsesLobe epilepsySurgical interventionElectron microscopic levelMesial structuresEctopic massBasket cellsEntorhinal cortexPyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy