2024
β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cells
2007
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
Andrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.Peer-Reviewed Original ResearchConceptsNeuronal lossProtein parvalbuminIntractable temporal lobe epilepsyCalcium binding protein parvalbuminParvalbumin-immunoreactive cellsTotal neuronal lossHippocampal neuronal lossParvalbumin-immunoreactive neuronsPV-ir neuronsHuman epileptic hippocampusMesial temporal structuresTemporal lobe epilepsyBinding protein parvalbuminTotal neuronal densityQuantitative stereological methodsAutopsy hippocampiAxonal reorganizationPV-irHippocampal sclerosisEpileptic hippocampusLobe epilepsyNeuronal densityInhibitory circuitsEpileptogenic processGABAergic interneurons4.12 Specializations of the Cortical Microstructure of Humans
DeFelipe J, Alonso-Nanclares L, Arellano J, Ballesteros-Yáñez I, Benavides-Piccione R, Muñoz A. 4.12 Specializations of the Cortical Microstructure of Humans. 2007, 167-190. DOI: 10.1016/b0-12-370878-8/00043-4.Peer-Reviewed Original ResearchHuman neocortexHuman cortical functionNeocortex of humansTypes of neuronsNumber of synapsesCerebral cortexGABAergic interneuronsCortical functionCortical areasCertain subtypesMicroanatomical studyNeocortexCortical microstructureNeocortical circuitsCortical organizationCortical structuresNeuronsInterneuronsCortexWide variationMammalian speciesLarger brainsHumansSynaptologyUnique specializations
2002
Microstructure of the neocortex: Comparative aspects
DeFelipe J, Alonso-Nanclares L, Arellano J. Microstructure of the neocortex: Comparative aspects. Brain Cell Biology 2002, 31: 299-316. PMID: 12815249, DOI: 10.1023/a:1024130211265.Peer-Reviewed Original ResearchConceptsDifferent cortical areasCortical areasExtrinsic afferent systemsNeocortex of humansInhibitory GABAergic interneuronsDensity of excitatoryNumber of synapsesSpecific cortical circuitsDistinct cortical areasSpiny cellsInhibitory circuitsGABAergic interneuronsInhibitory synapsesNeocortical neuronsNeuronal elementsPyramidal cellsAfferent systemsCortical circuitsNeocortical circuitsCortical tissueNumber of neuronsNeocortexNeuronsExcitatoryBasic microcircuit
2001
Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy