2024
β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cells
2023
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeuronsOld Models Know Wrinkles Best
Arellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.Peer-Reviewed Original Research
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2019
P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD
Datta D, Morozov Y, Arellano J, van Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD. Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.Peer-Reviewed Original Research
2012
Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells
Sarkisian M, Arellano J, Breunig J. Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-neuronal Cells. 2012, 105-129. DOI: 10.1007/978-94-007-5808-7_4.Peer-Reviewed Original ResearchCentral nervous systemPrimary ciliaCerebral cortexNeuronal ciliaCourse of evolutionPrimary neuronal ciliaPutative functionsPostnatal cerebral cortexNon-neuronal cellsMammalian cerebral cortexMaturation of cellsAbnormal ciliogenesisUnexpected roleCell typesCiliaCiliogenesisNervous systemPaucity of informationElectron microscopic studyCortexPattern of growthLack of methodsAvailable research toolsFurther investigationCells
2007
4.12 Specializations of the Cortical Microstructure of Humans
DeFelipe J, Alonso-Nanclares L, Arellano J, Ballesteros-Yáñez I, Benavides-Piccione R, Muñoz A. 4.12 Specializations of the Cortical Microstructure of Humans. 2007, 167-190. DOI: 10.1016/b0-12-370878-8/00043-4.Peer-Reviewed Original ResearchHuman neocortexHuman cortical functionNeocortex of humansTypes of neuronsNumber of synapsesCerebral cortexGABAergic interneuronsCortical functionCortical areasCertain subtypesMicroanatomical studyNeocortexCortical microstructureNeocortical circuitsCortical organizationCortical structuresNeuronsInterneuronsCortexWide variationMammalian speciesLarger brainsHumansSynaptologyUnique specializations
2006
Non-synaptic dendritic spines in neocortex
Arellano J, Espinosa A, Fairén A, Yuste R, DeFelipe J. Non-synaptic dendritic spines in neocortex. Neuroscience 2006, 145: 464-469. PMID: 17240073, DOI: 10.1016/j.neuroscience.2006.12.015.Peer-Reviewed Original Research
2002
PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex
Arellano J, DeFelipe J, Muñoz A. PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex. Cerebral Cortex 2002, 12: 617-624. PMID: 12003861, DOI: 10.1093/cercor/12.6.617.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsPSA-NCAMLayers IIAxon terminalsPlastic changesAdult central nervous systemPSA-NCAM immunoreactivityDouble immunocytochemical stainingHuman temporal cortexHuman entorhinal cortexCentral nervous systemPV-immunoreactiveTemporal neocortexSerotonin receptorsEntorhinal cortexTemporal cortexNervous systemAxonal processesGABA transporterImmunocytochemical stainingGAT-1ParvalbuminNeocortexCortexPresent study
2001
Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release
Persico A, Mengual E, Moessner R, Hall S, Revay R, Sora I, Arellano J, DeFelipe J, Giménez-Amaya J, Conciatori M, Marino R, Baldi A, Cabib S, Pascucci T, Uhl G, Murphy D, Lesch K, Keller F. Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release. Journal Of Neuroscience 2001, 21: 6862-6873. PMID: 11517274, PMCID: PMC6763105, DOI: 10.1523/jneurosci.21-17-06862.2001.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBiogenic MonoaminesCarrier ProteinsExtracellular SpaceFenclonineGABA Plasma Membrane Transport ProteinsImmunohistochemistryMembrane GlycoproteinsMembrane ProteinsMembrane Transport ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeurons, AfferentNeuropeptidesOrganic Anion TransportersSerotoninSerotonin AntagonistsSerotonin Plasma Membrane Transport ProteinsSomatosensory CortexSynapsesSynaptic VesiclesThalamusVesicular Biogenic Amine Transport ProteinsVesicular Monoamine Transport ProteinsVibrissaeConceptsVMAT2-KO miceDensity of synapsesKnock-out (KO) miceVesicular monoamine transporterThalamocortical afferentsCerebral cortexSynaptic contactsThalamocortical neuronsKO miceLayer IVBarrel cortexMonoamine releaseNeonatal rodentsBarrel fieldPostnatal growthVesicular releaseSerotonin transporterMonoamine transportersCortexPlasma membrane serotonin transporterSynaptic vesiclesQuantitative electron microscopyMiceComplete absenceRelease
1999
Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex
Elston G, DeFelipe J, Arellano J, del Carmen Gonzilez-Albo M, Rosa M. Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex. Neuroreport 1999, 10: 2975-2979. PMID: 10549808, DOI: 10.1097/00001756-199909290-00019.Peer-Reviewed Original ResearchConceptsPyramidal neuronesLayer VLucifer YellowSomatosensory cortexLayer IIICell bodiesRat primary somatosensory cortexTangential cortical slicesPrimary somatosensory cortexImmunoreactive cell bodiesBasal dendritic fieldsRat somatosensory cortexCombination of antibodiesReceptive field propertiesDendritic territoriesCortical slicesInhibitory modulationDendritic fieldsCortical neuronesIntracellular injectionNeuronesCortexConfocal microscopyFunctional implicationsSlices