2007
The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into Milk
VanHouten JN, Neville MC, Wysolmerski JJ. The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into Milk. Endocrinology 2007, 148: 5943-5954. PMID: 17823248, PMCID: PMC7108505, DOI: 10.1210/en.2007-0850.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportBlotting, WesternCalciumCells, CulturedEpithelial CellsFemaleFluorescent Antibody TechniqueGadoliniumIsoenzymesLactationMammary Glands, AnimalMiceMice, Inbred BALB CMicroscopy, ImmunoelectronMilkMilk ProteinsMutationOligonucleotide Array Sequence AnalysisPlasma Membrane Calcium-Transporting ATPasesReceptors, Calcium-SensingReverse Transcriptase Polymerase Chain ReactionConceptsPlasma membrane calcium ATPase isoform 2Mammary epithelial cellsMouse mammary epithelial cellsEpH4 mouse mammary epithelial cellsEpithelial cellsGenome-wide screening strategyApical plasma membraneATPase activityPotential downstream targetsATPase isoform 2Mouse mammary glandPlasma membrane preparationsDeafwaddler miceTransepithelial calcium transportPlasma membraneDownstream targetsGene knockdownPMCA2 activityCalcium transportIsoform 2Calcium-dependent ATPase activityCell membraneCultured primaryCalcium-sensing receptorPMCA2 expression
2000
Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53
Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2000, 12: 71-81. PMID: 11132926, DOI: 10.3727/096504001108747549.Peer-Reviewed Original ResearchAllelesAnimalsBlotting, WesternCarcinoma, Squamous CellCodonGene Expression Regulation, NeoplasticGenes, p53HumansMiceMutagenesis, Site-DirectedMutationMutation, MissenseParathyroid Hormone-Related ProteinPlasmidsPoint MutationPrecipitin TestsPromoter Regions, GeneticProtein ConformationProtein DenaturationProtein IsoformsProteinsRNA, MessengerTransfectionTumor Cells, CulturedTumor Suppressor Protein p53
1996
Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.
Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56: 4056-62. PMID: 8752179.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus E1B ProteinsCarcinoma, Squamous CellGene ExpressionGenes, p53Genes, ReporterHumansIsomerismKeratinocytesMutationParathyroid Hormone-Related ProteinPromoter Regions, GeneticProtein BiosynthesisProteinsRNA, MessengerTATA BoxTransfectionTumor Cells, CulturedTumor Suppressor Protein p53ConceptsHormone-related protein gene expressionPTHrP expression levelsSquamous carcinoma linesHormone-related proteinNormal secretory productP53 functional statusSquamous carcinoma cellsPTHrP gene expressionHuman squamous carcinoma cellsMutant p53 isoformsHumoral hypercalcemiaSquamous carcinomaFunctional statusPTHrP expressionPTHrP mRNASquamous epitheliumEndogenous mutant p53Mutant isoformsP53 isoformsCarcinoma linesWild-type p53Carcinoma cellsGene expressionCodon 248PTHrP transcripts