2012
PTHrP and breast cancer: more than hypercalcemia and bone metastases
Boras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research 2012, 14: 307. PMID: 22546075, PMCID: PMC3446368, DOI: 10.1186/bcr3129.BooksConceptsBone metastasesBreast cancerMMTV-PyMT miceNormal breast developmentPrimary breast tumorsHormone-related proteinBreast cancer susceptibility genesNew breast cancer susceptibility genesCancer patientsPrimary tumorCancer susceptibility genesClinical investigationBreast developmentBreast tumorsTumor growthPTHrPMetastasisHypercalcemiaTumorsCancerSusceptibility genesFurther researchPatientsMice
2011
Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice
Liu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research 2011, 27: 865-875. PMID: 22189918, DOI: 10.1002/jbmr.1503.Peer-Reviewed Original ResearchConceptsWhole bone stiffnessNulliparous miceBone microarchitectureTissue mineralizationBone mineral density BMDIndividual trabecula segmentationDramatic bone lossBone mineral densityBone stiffnessRecovered miceBone lossMineral densityPup weaningEffect of lactationMouse modelSkeletal sitesBone quantityClinical observationsMicro-finite element analysisBone qualitySite-specific changesSkeletal changesDigital topological analysisMiceCortical structuresSkeletal recovery after weaning does not require PTHrP*
Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP*. Journal Of Bone And Mineral Research 2011, 26: 1242-1251. PMID: 21308774, PMCID: PMC3179289, DOI: 10.1002/jbmr.339.Peer-Reviewed Original ResearchConceptsBone mineral contentParathyroid hormoneBone massSerum calciumLumbar spine bone mineral contentTrabecular bone mineral contentParathyroid hormone-related proteinSpine bone mineral contentBone formationNormal serum calciumLow bone massAdult bone massPTHrP mRNA expressionWild-type miceHormone-related proteinEnd of lactationType 1 collagenUrine calciumSkeletal recoveryPTHrP mRNANull miceMRNA expressionFull recoveryMiceConditional knockout
2008
Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in Paraffin
Dann P, Hens J, Troiano N, Wysolmerski J, Kacena M. Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in Paraffin. Journal Of Histotechnology 2008, 31: 61-64. DOI: 10.1179/his.2008.31.2.61.Peer-Reviewed Original ResearchWnt signaling in breast organogenesis
Boras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis 2008, 4: 116-122. PMID: 19279723, PMCID: PMC2634257, DOI: 10.4161/org.4.2.5858.BooksChapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic Tissues
Wysolmerski J, Stewart A, Kovacs C. Chapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic Tissues. 2008, 713-731. DOI: 10.1016/b978-0-12-373884-4.00051-3.ChaptersFunction of PTHrPParathyroid hormoneMammary glandNonskeletal effectsPancreatic tissueTransgenic miceEndocrine pancreasPTHrPPhysiological actionsPancreasPlacentaMicePhysiological roleGlandPhysiological functioningSkinMouse geneticsReproductive tissuesTissueStudy of physiologyRemarkable moleculeUterusPhysiologyMammaryStudy
2005
TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*
Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*. Journal Of Bone And Mineral Research 2005, 20: 1103-1113. PMID: 15940363, DOI: 10.1359/jbmr.050210.Peer-Reviewed Original ResearchConceptsTOPGAL miceBone developmentCanonical WntMature skeletonNeonatal bone developmentCanonical Wnt Signaling PathwayExpression of WntActivation of WntWnt Signaling PathwayX-gal stainingCalvarial cellsT-cell factorBone massCanonical Wnt activityCanonical Wnt signalingPrimary calvarial cell culturesMiceAnabolic activityPrimary calvarial cellsRT-PCRCell factorCultured calvarial cellsNeonatal skeletonCollagen ISignaling pathways
2002
Nipple connective tissue and its development: insights from the K14-PTHrP mouse
Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Cells And Development 2002, 115: 63-77. PMID: 12049768, DOI: 10.1016/s0925-4773(02)00092-8.Books
1998
PTHrP Regulates Epidermal Differentiation in Adult Mice
Foley J, Wysolmerski J, Dreyer B, Broadus A, Philbrick W, Longely B. PTHrP Regulates Epidermal Differentiation in Adult Mice. Journal Of Investigative Dermatology 1998, 111: 1122-1128. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceKeratin 14 promoterAdult miceSebaceous glandsHuman keratin 14 promoterParathyroid hormone-related peptideHyperplastic sebaceous glandsHormone-related peptideAbsence of PTHrPNumber of organsWk of agePremature acquisitionEpidermal proliferation rateMarked acanthosisTransgenic replacementReciprocal findingsTransgenic micePTHrPPTHrP geneMiceMammary glandBasal keratinocytesDisplay abnormalitiesLethal chondrodystrophyFibrotic dermis
1994
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.Peer-Reviewed Original ResearchConceptsFollicle developmentTransgenic miceHair follicle developmentHuman keratin 14 promoterParathyroid hormone-related proteinNormal hair follicle developmentOverexpression of PTHrPHormone-related proteinHormone-related peptideKeratin 14 promoterHumoral hypercalcemiaPTHrP geneNormal tissuesMicePTHrPSkinOverexpressionCellular differentiationEarly stagesHypercalcemiaMalignancySyndromePeptidesFollicles