2021
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Reports 2021, 37: 110160. PMID: 34965434, PMCID: PMC8762588, DOI: 10.1016/j.celrep.2021.110160.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, ImmunologicalBreast NeoplasmsCell ProliferationCytoskeletal ProteinsDrug Resistance, NeoplasmEndocytosisFemaleHumansMembrane MicrodomainsMyelin and Lymphocyte-Associated Proteolipid ProteinsPhosphoproteinsPlasma Membrane Calcium-Transporting ATPasesReceptor, ErbB-2Sodium-Hydrogen ExchangersTrastuzumabTumor Cells, CulturedConceptsLipid raft formationBreast cancer cellsLipid raftsLipid raft resident proteinsCancer cellsRaft formationRaft-resident proteinsProximity ligation assayProtein complexesMembrane protrusionsProtein interactionsPlasma membraneLigation assayMAL2Membrane stabilityStructural organizationPotential therapeutic targetPhysical interactionMembrane retentionProteinRaftsTherapeutic targetCellsIntracellular calcium concentrationLow intracellular calcium concentration
2013
Attacking Breast Cancer at the Preinvasion Stage by Targeting Autophagy
Espina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking Breast Cancer at the Preinvasion Stage by Targeting Autophagy. Women's Health 2013, 9: 157-170. PMID: 23477322, PMCID: PMC3779365, DOI: 10.2217/whe.13.5.BooksConceptsBreast cancerBreast cancer stem-like cellsCancer stem-like cellsBreast carcinoma cellsStem-like cellsDuctal carcinomaPreinvasive carcinomaPreinvasive neoplasmsClinical trialsIntracellular calciumSevere hypoxicTherapeutic strategiesNeoplastic cellsCarcinoma cellsMetabolic stressCarcinomaTherapyCancerCellsSurvival mechanismAutophagyNeoplasmsTrialsHypoxic
2009
Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis
Hens J, Dann P, Hiremath M, Pan T, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics 2009, 238: 2713-2724. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 4Cells, CulturedDipeptidesDown-RegulationGene Expression Regulation, DevelopmentalHydroxamic AcidsIntercellular Signaling Peptides and ProteinsKeratinsMammary Glands, AnimalMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMesodermMiceMice, KnockoutMorphogenesisOligonucleotide Array Sequence AnalysisParathyroid Hormone-Related ProteinProtease InhibitorsSignal TransductionTranscription FactorsUp-RegulationConceptsGene expressionMammary budMammary mesenchymeDuctal outgrowthMesenchymal cellsEmbryonic mammary developmentMMP2 gene expressionEmbryonic mammary budFunctional roleGenesDuctal morphogenesisBud culturesMammary developmentBudsPTHrP effectsBMPMesenchymeExpressionMMP2 activityMMP2OutgrowthVentral skinCellsMorphogenesisBMP4
1999
The Role of PTHrP in Mammary Gland Development and Tumorigenesis
Wysolmerski J. The Role of PTHrP in Mammary Gland Development and Tumorigenesis. 1999 DOI: 10.21236/ada386538.Peer-Reviewed Original ResearchEmbryonic developmentMammary glandMesenchymal cellsMammary epithelial ductsEmbryonic mammary developmentMammary bud formationMammary gland developmentCell fateTransient overexpressionMammary morphogenesisEpithelial developmentEmbryonic formationBud formationGland developmentEpithelial budsEpithelial ductsMammary developmentMorphogenesisEpithelial cellsProfound consequencesOverexpressionTumorigenesisCellsDermal cellsMammary tumorigenesis