2023
Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy
Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaLow-dose radiation therapyPeriorbital edemaRadiation therapyChronic Lymphocytic Leukemia PresentingBilateral periorbital edemaLeukemia cutisOcular involvementOcular manifestationsPrompt diagnosisBlood dyscrasiasCase reportNeoplastic lymphocytesLymphocytic leukemiaTissue infiltrationTherapeutic interventionsEdemaPatientsTherapyLeukemiaInfiltrationEcchymosisPresentingDyscrasiasLymphocytesNK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature
Dhodapkar R, Spadaro J, Heng J, Sinard J, Lee Y, Habib L, Pointdujour-Lim R. NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: 316-327. PMID: 36692957, DOI: 10.1097/iop.0000000000002317.Peer-Reviewed Original ResearchConceptsNK/T-cell lymphomaT-cell lymphomaImproved survivalOrbital involvementCases of NKTLAdvanced Ann Arbor stageAnn Arbor stageRecurrence of diseaseUse of radiotherapyLacrimal drainage systemMedian survivalPeriorbital swellingSurgical debulkingClinical courseMean agePoor prognosisOcular adnexaCase reportTumor locationVision lossPoor survivalEarly diagnosisLacrimal glandOcular structuresPubMed databaseComputational pathology in 2030: a Delphi study forecasting the role of AI in pathology within the next decade
Berbís M, McClintock D, Bychkov A, Van der Laak J, Pantanowitz L, Lennerz J, Cheng J, Delahunt B, Egevad L, Eloy C, Farris A, Fraggetta F, del Moral R, Hartman D, Herrmann M, Hollemans E, Iczkowski K, Karsan A, Kriegsmann M, Salama M, Sinard J, Tuthill J, Williams B, Casado-Sánchez C, Sánchez-Turrión V, Luna A, Aneiros-Fernández J, Shen J. Computational pathology in 2030: a Delphi study forecasting the role of AI in pathology within the next decade. EBioMedicine 2023, 88: 104427. PMID: 36603288, PMCID: PMC9823157, DOI: 10.1016/j.ebiom.2022.104427.Peer-Reviewed Original Research
2022
Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders
Darbinian N, Darbinyan A, Sinard J, Tatevosian G, Merabova N, D’Amico F, Khader T, Bajwa A, Martirosyan D, Gawlinski A, Pursnani R, Zhao H, Amini S, Morrison M, Goetzl L, Selzer M. Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders. International Journal Of Molecular Sciences 2022, 24: 135. PMID: 36613580, PMCID: PMC9820501, DOI: 10.3390/ijms24010135.Peer-Reviewed Original ResearchConceptsCaspase-3 activityBrain-derived exosomesMarker of synaptogenesisBrain caspase-3 activityFetal alcohol spectrum disordersMaternal blood samplesPrenatal alcohol exposureHuman fetal brainAlcohol spectrum disordersAvailable imaging techniquesMyelin basic proteinEtOH intakeEtOH exposureEtOH useMaternal raceNeurobehavioral deficitsAlcohol exposureMaternal bloodMother's bloodEarly diagnosisFetal brainBlood samplesMBP levelsTherapeutic interventionsBrain sizeSystems approach to enhance Lynch syndrome diagnosis through tumour testing
Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.Peer-Reviewed Original ResearchConceptsOriginal cohortColorectal adenocarcinomaLynch syndromeTumor testingGenetic testingPercentage of patientsProportion of patientsLynch syndrome diagnosisCG evaluationCancer genetic testingRace/ethnicityCRC testingCohort studyMMR immunohistochemistryLS diagnosisNew diagnosisMMR lossAcademic centersPatientsSyndrome diagnosisCohortCase identificationMethylation testingReferral differencesReferral mechanismsPrimary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa)
Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B. Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa). Head And Neck Pathology 2022, 16: 716-727. PMID: 35218514, PMCID: PMC9424363, DOI: 10.1007/s12105-022-01428-7.Peer-Reviewed Original ResearchConceptsMalignant perivascular epithelioid cell tumorPerivascular epithelioid cell tumorEpithelioid cell tumorPrimary mesenchymal tumorsMesenchymal tumorsThyroid glandCell tumorsPeripheral nerve sheath tumorsNerve sheath tumorsSmall case seriesBiphasic synovial sarcomaOnly case reportsSolitary fibrous tumorAnaplastic thyroid carcinomaMulti-centric cohortFirst caseRetrospective cohortEpithelioid hemangioendotheliomaSheath tumorsTertiary centerCase seriesClinicopathologic featuresFemale patientsSynovial sarcomaCase report
2021
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstate
2020
Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan
McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicHealth care worker safetyCoronavirus 2 pandemicCOVID-19 public health emergencyHigh-quality patient carePublic health emergencyCorona Virus DiseaseEarly response phaseInfection controlPatient careTissue retrievalAutopsy serviceMortuary servicesHospital mortuaryAutopsiesHealth emergencyPatient flowNovel diseaseVirus diseasePlateau phaseDiseasePandemicRecent memoryEmergency preparednessProtecting the Pathology Commons in the Digital Era
Mazer BL, Paulson N, Sinard JH. Protecting the Pathology Commons in the Digital Era. Archives Of Pathology & Laboratory Medicine 2020, 144: 1037-1040. PMID: 32579394, DOI: 10.5858/arpa.2020-0022-ed.Peer-Reviewed Original ResearchHistopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation
Maslin JS, Chen PP, Sinard J, Nguyen AT, Noecker R. Histopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation. Canadian Journal Of Ophthalmology 2020, 55: 330-335. PMID: 32446502, DOI: 10.1016/j.jcjo.2020.03.010.Peer-Reviewed Original ResearchConceptsMicropulse transscleral cyclophotocoagulationHuman cadaver eyesCiliary bodyTransscleral cyclophotocoagulationCadaver eyesPigment clumpingPigmented ciliary epitheliumTissue damageCiliary epitheliumMinimal histologic changesLess tissue disruptionAcute histological effectsDifferent treatment areasPathologic evaluationHistologic changesHistological effectsTreatment groupsCyclophotocoagulationCiliary processesHistologic processingSenior pathologistAdjacent structuresStandard histologic processingTissue sectionsEyesPulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis.
Li E, Sinard J, Sohrab M. Pulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 2020, 36: e28-e30. PMID: 31789787, DOI: 10.1097/iop.0000000000001534.Peer-Reviewed Original ResearchConceptsOrbital inflammationAdenocarcinoma metastaticMetastatic lung cancerLife-saving managementIntraorbital soft tissuesBroad-spectrum antibioticsOccult malignancyAdjuvant radiationSystemic chemotherapyInitial presentationOrbital cellulitisLung cancerPeriocular skinSubcutaneous massHigh indexTissue biopsiesSoft tissueMetastaticBiopsyInflammationDiagnosisFirst reportCellulitisChemotherapyPatients
2019
A Survey of LOINC Code Selection Practices Among Participants of the College of American Pathologists Coagulation (CGL) and Cardiac Markers (CRT) Proficiency Testing Programs
Stram M, Seheult J, Sinard JH, Campbell WS, Carter AB, de Baca ME, Quinn AM, Luu HS, Pathologists O. A Survey of LOINC Code Selection Practices Among Participants of the College of American Pathologists Coagulation (CGL) and Cardiac Markers (CRT) Proficiency Testing Programs. Archives Of Pathology & Laboratory Medicine 2019, 144: 586-596. PMID: 31603714, DOI: 10.5858/arpa.2019-0276-oa.Peer-Reviewed Original ResearchMeSH KeywordsCanadaClinical CodingClinical Laboratory Information SystemsDatabases, FactualElectronic Health RecordsHumansLaboratoriesLaboratory Proficiency TestingLogical Observation Identifiers Names and CodesPathologistsReproducibility of ResultsSocieties, MedicalSurveys and QuestionnairesUnited StatesConceptsCode selectionLogical Observation IdentifiersHealth information systemsHealth care dataElectronic health recordsInformation systemsBiomedical terminologiesTerminology mappingLOINC codesLOINC databaseCode implementationHigh error rateHealth recordsSelection of panelsIncorrect componentsError rateProficiency testing programAmerican Pathologists Proficiency Testing ProgramCodeCare dataCRT participantsPatient outcomesInteroperabilityPractice settingsClinical researchA Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma
Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.Peer-Reviewed Original ResearchImmune Checkpoint Inhibitor–Associated Pericarditis
Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.Peer-Reviewed Original ResearchConceptsAdverse eventsCTLA-4 inhibitorsImmune checkpoint inhibitorsDeath-1/Pericardial window procedureCheckpoint inhibitorsThird patientClinical presentationCardiac toxicityHistopathologic findingsSide effectsPericarditisPatientsDeath ligandsPotential mechanismsWindow procedureInhibitorsImmunotherapyNSCLCCardiotoxicityAutopsiesTherapy
2018
Pleomorphic lipoma of the bulbar conjunctiva
Li E, Silbert J, Sinard J. Pleomorphic lipoma of the bulbar conjunctiva. BMJ Case Reports 2018, 11: e226548. PMID: 30567236, PMCID: PMC6301450, DOI: 10.1136/bcr-2018-226548.Peer-Reviewed Original ResearchEpithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation
Li E, Distefano A, Sinard J, Wong A, Pointdujour-Lim R. Epithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. Ophthalmic Plastic And Reconstructive Surgery 2018, 34: e157-e160. PMID: 30080758, DOI: 10.1097/iop.0000000000001179.Peer-Reviewed Original ResearchConceptsVeno-lymphatic malformationEpithelial-myoepithelial carcinomaRight eye painAdjuvant radiation therapyComplete surgical excisionFluid-fluid levelsIntralesional cystsEye painCarcinoma presentingSurgical excisionFinal diagnosisHistopathologic evaluationRadiologic workupRare neoplasmCystic spacesRadiation therapySalivary glandsPainCarcinomaMalformationsPresentingNeoplasmsHistopathologyTherapyWorkupOrbital cellulitis with choroidal detachment following strabismus surgery in an adult
Kim JM, Megalla M, Howard M, Sinard J, Pointdujour-Lim R. Orbital cellulitis with choroidal detachment following strabismus surgery in an adult. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 477-480. PMID: 30171895, DOI: 10.1016/j.jaapos.2018.04.016.Peer-Reviewed Original ResearchConceptsChoroidal detachmentStrabismus surgeryOrbital cellulitisLeft eye painPostoperative day 9Intravenous antibiotic useMethicillin-resistant Staphylococcus aureusDrainable abscessEye painExtraocular motilityEyelid swellingVisual acuityAntibiotic useRetrobulbar abscessDural enhancementComputed tomographyDay 9AbscessSurgeryCellulitisPainStaphylococcus aureusMagnetic resonanceFirst reportDetachmentOptimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessmentBilateral Cicatrizing Conjunctivitis in a Middle-aged Man
Apostolopoulos N, Sinard J, Kombo N. Bilateral Cicatrizing Conjunctivitis in a Middle-aged Man. JAMA Ophthalmology 2018, 136: 706-707. PMID: 29596593, DOI: 10.1001/jamaophthalmol.2017.5490.Peer-Reviewed Original Research
2017
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Tainsh LT, Coady PA, Sinard JH, Neparidze N, Meskin SW, Adelman RA, Chow J. Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. Cornea 2017, 36: 372-374. PMID: 28079685, DOI: 10.1097/ico.0000000000001139.Peer-Reviewed Original ResearchConceptsMultiple myelomaVisual acuityRight eye 2 yearsDeep stromal opacitiesEye 2 yearsPatient's visual acuityDiagnosis of IgGParaproteinemic keratopathyInitial presentationStromal lesionsStromal opacityCase reportHematologic workupMonoclonal gammopathyAsymmetric presentationUnusual casePosterior stromaMyelomaKeratopathyPatientsDiagnosisPresentationLiterature reviewKeratoplastyAcuity