Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks
Suljič N, Kraljič A, Rahmati M, Cho Y, Ozimič A, Murray J, Anticevic A, Repovš G. Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks. Cerebral Cortex 2024, 34: bhae350. PMID: 39214852, PMCID: PMC11364466, DOI: 10.1093/cercor/bhae350.Peer-Reviewed Original ResearchConceptsCategorical representationsWorking memoryBrain activityFunctional magnetic resonance imaging studySpatial working memory strategySpatial working memory taskFrontoparietal network activitySpatial working memoryWorking memory taskEngagement of controlAssociated with distinct patternsWorking memory strategiesMagnetic resonance imaging studiesNetwork activityMemory taskBrain systemsAttentional resourcesTask trialsBrain networksMemory strategiesStimulus informationStronger deactivationTiming of stimuliHealthy participantsSpatial representationKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbumin