Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics
Demirtaş M, Burt JB, Helmer M, Ji JL, Adkinson BD, Glasser MF, Van Essen DC, Sotiropoulos SN, Anticevic A, Murray JD. Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics. Neuron 2019, 101: 1181-1194.e13. PMID: 30744986, PMCID: PMC6447428, DOI: 10.1016/j.neuron.2019.01.017.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityHigh-frequency spectral powerMagnetic resonance imagingLocal synaptic strengthsResting-state magnetoencephalographyCircuit-level mechanismsMicrocircuit propertiesHuman cortical dynamicsCortical areasLocal circuitsResonance imagingSynaptic strengthHuman cortexFunctional MRIFunctional connectivityCortical organizationHierarchical specializationLarge-scale neural dynamicsNeural activityFMRI featuresCortexCortical dynamicsLocal propertiesSpectral powerIntrinsic local propertiesA circuit mechanism for decision-making biases and NMDA receptor hypofunction
Cavanagh SE, Lam NH, Murray JD, Hunt LT, Kennerley SW. A circuit mechanism for decision-making biases and NMDA receptor hypofunction. ELife 2020, 9: e53664. PMID: 32988455, PMCID: PMC7524553, DOI: 10.7554/elife.53664.Peer-Reviewed Original ResearchConceptsNMDA-R hypofunctionCortical excitation/inhibition balanceExcitation/inhibition balanceNMDA receptor hypofunctionNMDA receptor antagonismNMDA-R antagonist ketamineCircuit-level mechanismsPotential neural mechanismsNeuropsychiatric symptomsReceptor hypofunctionReceptor antagonismInhibition balanceExcitatory neuronsInhibitory neuronsPharmacological modelPharmacological manipulationNeuropsychiatric disordersCircuit mechanismsHypofunctionVariable evidenceNeural mechanismsKetamineNeuronsBehavioral psychophysicsPossible effects