2024
Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus
Lee S, Cho S, Lee J, Kim J, Kim S, Jeong M, Hong J, Kim G, Lee S, Kim E, Kim J, Kim J, Hwa J, Kim W. Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus. Diabetology & Metabolic Syndrome 2024, 16: 149. PMID: 38970135, PMCID: PMC11225187, DOI: 10.1186/s13098-024-01390-0.Peer-Reviewed Original ResearchDiabetes mellitusCardiac fibrosisDiabetic cardiomyopathyReactive oxygen speciesAbnormal electrophysiological functionIncreased cardiac fibrosisMethionine sulfoxide reductase B2Chronic metabolic disorderIncreased ROSDiabetic mouse modelCardiac complicationsCardiac damageHeart failureKnockout miceDM miceElectrophysiological functionMouse modelHeart damageMetabolic disordersHistological analysisStructural pathologyCardiac tissueMiceExcessive reactive oxygen speciesHeart samples
2016
Inducing mitophagy in diabetic platelets protects against severe oxidative stress
Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Molecular Medicine 2016, 8: 779-795. PMID: 27221050, PMCID: PMC4931291, DOI: 10.15252/emmm.201506046.Peer-Reviewed Original ResearchConceptsDiabetes mellitusOxidative stressThrombotic cardiovascular eventsAnticipation of exposureCardiovascular eventsOxidative stress-mediated mitochondrial damageNormal platelet activationDiabetic plateletsPlatelet functionPlatelet pathologyPlatelet activationSevere oxidative stressNormal plateletsConsiderable mortalityProtective mechanismMitochondrial damageMellitusThrombosisPlateletsMitophagy inductionPhosphorylated p53Mitophagy machineryPlatelets resultsAutophagy processJNK activation
2015
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor
Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood 2015, 125: 3377-3387. PMID: 25814526, PMCID: PMC4447857, DOI: 10.1182/blood-2015-01-620278.Peer-Reviewed Original ResearchConceptsVon Willebrand factorDiabetes mellitusMiR-24Diabetic patientsAdverse thrombotic eventsThrombotic cardiovascular eventsVWF expressionWillebrand factorDiabetic mouse modelNovel therapeutic targetHistamine H1 receptorsEndothelial cell expressionHyperglycemia-induced activationCardiovascular eventsThrombotic eventsH1 receptorsMouse modelVWF levelsTherapeutic targetCell expressionMellitusPatientsEndothelial cellsElevated levelsReactive oxygen species