John Geibel, DSc, MD, AGAF, MS, FRS
Professor Emeritus of Surgery (Gastrointestinal)Cards
Additional Titles
Vice Chair, Surgery
Director, Surgical Research
American Gastroenterological Association Fellow
Fellow of the Royal Society of Medicine
Contact Info
Gastrointestinal Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
About
Titles
Professor Emeritus of Surgery (Gastrointestinal)
Vice Chair, Surgery; Director, Surgical Research; American Gastroenterological Association Fellow; Fellow of the Royal Society of Medicine
Biography
John Geibel is Vice Chairman of the Department of Surgery at Yale School of Medicine and Director of Surgical Research and Professor of Cellular and Molecular Physiology. His early research training was in Innsbruck Austria where he worked in the Physiology Department and investigated renal physiology on the isolated perfused tubule model. He holds a Bachelors of Science Degree in Physiology, an MD and DSc degree as well as a Master’s of Science, and a Master’s of Arts Degree. He has also obtained his Dozent in Medicine from the University of Innsbruck. After obtaining his Dozent he went to Yale University first as a visiting fellow and then joined the faculty in both Surgery and Cellular and Molecular Physiology where he rose through the ranks to Professor in both faculties.
Academically, Professor Geibel’s active research interests are on the role of the Calcium Sensing Receptor (CaSR) in gastrointestinal physiology and pathophysiology. In addition, John Geibel has conducted research in fluid and electrolyte transport in the intestine where he was the first to identify that the colonic crypt can both actively secrete and absorb fluid. He has also identified 4 new transport pathways in the stomach that play important roles in acid secretion and may help to explain some of the hypersecretion of acid that occurs in patients. In addition he maintains a research program in the kidney where he was the first to identify a functional role for the H-ATPase in the proximal tubule; he was also the first to demonstrate a role for Angiotensin on the Na/H exchanger and Na/HCO3 and H-ATPase in the proximal tubule. Professor Geibel is the author of over 250 publications and presents his findings both nationally and internationally. He is the holder of 10 patents on the role of the calcium sensing receptor on gastrointestinal models and is currently actively working to begin clinical trials on a method to stop secretory diarrhea in the developing world based on targeting the calcium sensing receptor. He has also patented a new method to suppress acid secretion. Recently Dr. Geibel has actively developed a 3D Bioprinting program for vascular anomalies and intestinal repair.
Departments & Organizations
- Cancer Signaling Networks
- Geibel Lab
- Graduate Program in Cellular and Molecular Physiology
- Surgery
- Yale Cancer Center
- Yale Ventures
Education & Training
- MD
- University of Innsbruck (1986)
- DSc
- University of Innsbruck (1983)
- MS
- University of New Brunswick, Physiology (1981)
Research
Overview
We are focused on 3 main areas; gastric ion transport in health and disease, intestinal ion transport in health and disease, and 3DBioprinting. For gastric ion transport we are focusing on means to modulate acid secretion and reverse erosion. We use a combination of natural products and biochemical modifications to treat acid disease at the cellular level. For studies of intestinal ion transport, we are focusing on how the calcium sensing receptor(CaSR) can modulate fluid transport during toxin induced diarrhea. We are also looking at nanoparticle therapies for Ulcerative Colitis. In addition we are investigating means to prevent ischemic injury by activating ionic pathways using the AMPKinase. Finally we are trying to prevent IBD/IBS associated epithelial injury in the gut by CaSR activation using nutraceuticals . For the 3DBioprinting area we are developing replacement conduits that can be used for the aorta, the inferior vena cava, and also as small and large intestine repair tool. Along with this research we are now examining the potential for intestinal elongation using a 3D printed replacement.
Medical Research Interests
ORCID
0000-0003-1147-7501
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
David Mulligan, MD, FACS, FAST, FAASLD
Henry J. Binder, MD
Marie Egan, MD
Karin Finberg, MD, PhD
Michael Caplan, PhD, MD
Abedalrazaq Alkukhun, MBBS, MPH
Gastric Acid
Diarrhea
Bioprinting
Electrophysiology
Gastroenterology
Publications
2023
Application of a 3D Bioprinter: Jet Technology For ‘Biopatch’ Development Using Cells on Hydrogel Supports
DeMel D, Wagner G, Maresca J, Geibel J. Application of a 3D Bioprinter: Jet Technology For ‘Biopatch’ Development Using Cells on Hydrogel Supports. BioTechniques 2023, 76: 52-62. PMID: 38084384, DOI: 10.2144/btn-2023-0052.Peer-Reviewed Original ResearchThree-Dimensional Bioprinting Applications for Bone Tissue Engineering
Maresca J, DeMel D, Wagner G, Haase C, Geibel J. Three-Dimensional Bioprinting Applications for Bone Tissue Engineering. Cells 2023, 12: 1230. PMID: 37174630, PMCID: PMC10177443, DOI: 10.3390/cells12091230.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBone tissue engineeringThree-dimensional (3D) bioprinting applicationsTissue engineeringSupport structureAdditional support structuresUse of hydrogelsBioprinting applicationsBone replacementNormal bone physiologyQuality of lifeBioprintingKey support structuresBone physiologyInjurySkeletal systemEngineeringMultiple directionsBiological materialsForeign objectsHydrogelsNew techniquePrinterPatientsPathophysiologyDegenerationCRITICALITIES AND USEFULNESS OF EX-VIVO SMALL INTESTINE PERFUSION: TRANSPLANT AND BEYOND
Muñoz-Abraham A, Martinez A, Aviles-Ovalle B, Patron-Lozano R, D’Amico F, Geibel J, Mulligan D, Martins P, Rodriguez-Davalos M. CRITICALITIES AND USEFULNESS OF EX-VIVO SMALL INTESTINE PERFUSION: TRANSPLANT AND BEYOND. European Journal Of Transplantation 2023, 1: 126-135. DOI: 10.57603/ejt-015.Peer-Reviewed Original Research
2022
3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications
Dell A, Wagner G, Own J, Geibel J. 3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications. Pharmaceutics 2022, 14: 2596. PMID: 36559090, PMCID: PMC9784738, DOI: 10.3390/pharmaceutics14122596.Peer-Reviewed Original ResearchCitationsConceptsTissue engineering applicationsPrintable formulationsBioprinting processEngineering applicationsProcess optimizationBioprinting methodInk formulationTissue engineeringTailorable materialsBioprintingBiomedical applicationsBiological tissuesHydrogelsNew hydrogelsInkPromising optionNovel methodApplicationsBiological applicationsFormulationVariety of techniquesEngineeringMethodMaterialsL-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchCitationsConceptsIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusionColonic Fluid and Electrolyte Transport 2022: An Update
Negussie AB, Dell AC, Davis BA, Geibel JP. Colonic Fluid and Electrolyte Transport 2022: An Update. Cells 2022, 11: 1712. PMID: 35626748, PMCID: PMC9139964, DOI: 10.3390/cells11101712.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCystic fibrosis transmembrane regulatorCell death regulationSignal transduction pathwaysDeath regulationNa-K-Cl cotransporterEpithelial cell deathTransduction pathwaysIon homeostasisRegulatory relationshipsIon transportersTransepithelial ion transportEpithelial sodium channelTransmembrane regulatorCell deathColonic epithelial cellsEpithelial cellsTransportersSodium channelsNa-H exchangerRegulationIon transportCancer pathologyPH modulationIon movementOsmotic gradientGastric secretions
Geibel J. Gastric secretions. 2022, 313-333. DOI: 10.1002/9781119600206.ch17.Peer-Reviewed Original Research
2021
3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications
Chen EP, Toksoy Z, Davis BA, Geibel JP. 3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications. Frontiers In Bioengineering And Biotechnology 2021, 9: 664188. PMID: 34055761, PMCID: PMC8158943, DOI: 10.3389/fbioe.2021.664188.Peer-Reviewed Original ResearchCitationsAltmetricConceptsThree-dimensional (3D) bioprinting technologyFunctional replacement organsBioprinting technologyTissue engineeringWaste disposalBioprintingVascularized tissuesComplex tissue architectureRelevant applicationsOrgan replacementLatest advancementsComplex vascular networkMaterialsApplicationsReplacement organsCurrent limitationsMain challengesNumerous combinationsTechnologyRapid developmentEngineeringVascular networkVivo applicationsBile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario
D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBile microbiotaLiver donorsBiliary tract diseaseCommon bile ductGene amplificationRibosomal RNA gene amplificationLiver recipientsLiver transplantationPediatric recipientsLiver proceduresBiliary tractBile ductRecipient patientsTract diseaseBile samplesHeterogeneous cohortClinical scenariosBileSterile wayPCR sequencingPatientsRecipientsMicrobiotaTransplantationGallbladder
2020
Hydrogel‐based 3D bioprints repair rat small intestine injuries and integrate into native intestinal tissue
Maina RM, Barahona MJ, Geibel P, Lysyy T, Finotti M, Isaji T, Wengerter B, Mentone S, Dardik A, Geibel JP. Hydrogel‐based 3D bioprints repair rat small intestine injuries and integrate into native intestinal tissue. Journal Of Tissue Engineering And Regenerative Medicine 2020, 15: 129-138. PMID: 33197151, DOI: 10.1002/term.3157.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsIntestinal segmentsPost-operative day 7Male Sprague-Dawley ratsMale Wistar ratsSmall intestine injurySprague-Dawley ratsNative intestineBlinded histopathological analysisIntestinal failureStool outputNative intestinal tissueIntestine injuryIntraluminal perfusionRat vascular cellsHistopathological analysisIleocecal junctionWistar ratsIntestinal integrityIntestinal tissueDay 7Small intestineGenetic malformationsNormal activityWeight gainEnterotomy
Academic Achievements & Community Involvement
activity New Insights in 3D Bioprinting from Vessels to Intestines
Other3D Biprinting World CongressDetails04/18/2019 - 10/20/2019Mainz, RP, GermanySponsored by University of MainzAbstract/SynopsisPlenary Speaker at 3D Bioprinting World Congress
honor America's Top Doctors
National AwardResearch Council of AmericaDetails08/09/2019United Stateshonor Doctor of Medicine h.c.
International AwardParacelsus Medical UniversityDetails05/01/2019Austriahonor America's Top Doctors
National AwardResearch Council of AmericaDetails05/07/2018United Statesactivity eMedicine
Peer Review Groups and Grant Study SectionsMemberDetailsEditor in Chief of eMedicine1995 - 2014
News & Links
Media
- Isolated gastric gland loaded with the pH sensitive dye BCECF and a lysosomal tracker on a Zeiss Spinning Disk confocal. Image shows 3-D reconstruction of the gland in real time.
News
- April 17, 2020
A new dimension to intestinal surgery
- September 12, 2017
Research in Surgery: A Brief Historical Overview
- February 12, 2016
Keeping the “Goldilocks” organ cool
- February 12, 2016
New artery? We can print that
Get In Touch
Contacts
Gastrointestinal Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
Yale University
BML 232, 310 Cedar Street
New Haven, CT 06510
United States
Administrative Support
Locations
Brady Memorial Laboratory
Lab
310 Cedar Street, Ste 269/2
New Haven, CT 06510
General Information
203.737.1475Appointments
203.737.1485