2023
“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatmentPyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta
Liang L, Liu M, Elefteriades J, Sun W. PyTorch-FEA: Autograd-enabled finite element analysis methods with applications for biomechanical analysis of human aorta. Computer Methods And Programs In Biomedicine 2023, 238: 107616. PMID: 37230048, PMCID: PMC10330852, DOI: 10.1016/j.cmpb.2023.107616.Peer-Reviewed Original ResearchConceptsDeep neural networksFinite element analysisFEA codeImproved loss functionInverse methodFinite element analysis methodInverse problemCommercial FEA software packageElement analysis methodFEA software packageCommercial FEA packageNew libraryNeural networkPerformance issuesFEA packageNew inverse methodBiomechanical analysisComputational timeFEA methodLoss functionSolid mechanicsDeformation analysisSoftware packageInverse analysisSeries of applicationsAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesExtended law of laplace for measurement of the cloverleaf anatomy of the aortic root
Ban E, Kalogerakos P, Khosravi R, Ziganshin B, Ellauzi H, Ramachandra A, Zafar M, Humphrey J, Elefteriades J. Extended law of laplace for measurement of the cloverleaf anatomy of the aortic root. The International Journal Of Cardiovascular Imaging 2023, 39: 1345-1356. PMID: 37046157, PMCID: PMC10250276, DOI: 10.1007/s10554-023-02847-5.Peer-Reviewed Original ResearchFate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteriaAortic Root Diameter in Elite Athletes
Elefteriades J. Aortic Root Diameter in Elite Athletes. Canadian Journal Of Cardiology 2023, 39: 898-900. PMID: 36963721, DOI: 10.1016/j.cjca.2023.03.015.Peer-Reviewed Original Research
2022
No Shame in Sole Ascending Aortic Replacement for Acute Type A Aortic Dissection
Elefteriades J. No Shame in Sole Ascending Aortic Replacement for Acute Type A Aortic Dissection. The Annals Of Thoracic Surgery 2022, 115: 895. PMID: 36460063, DOI: 10.1016/j.athoracsur.2022.11.014.Peer-Reviewed Original Research
2005
Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta
Koullias G, Modak R, Tranquilli M, Korkolis DP, Barash P, Elefteriades JA. Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta. Journal Of Thoracic And Cardiovascular Surgery 2005, 130: 677.e1-677.e9. PMID: 16153912, DOI: 10.1016/j.jtcvs.2005.02.052.Peer-Reviewed Original ResearchConceptsMechanical characteristicsMechanical deteriorationHuman ascending aortaAortic aneurysmAortic wall stressNormal aortaAneurysmal aortaAortic distensibilityAscending aortaMalignant behaviorAortic wallWall stressMaximal tensile strengthMechanical propertiesCoronary artery bypassTensile strengthTime of surgeryAortic wall thicknessAscending Aortic AneurysmMalignant clinical behaviorElastic modulusHuman ascending aortic aneurysmsEngineering analysisAneurysmal aortic wallMechanical substrate
1999
NATURAL HISTORY, PATHOGENESIS, AND ETIOLOGY OF THORACIC AORTIC ANEURYSMS AND DISSECTIONS
Coady M, Rizzo J, Goldstein L, Elefteriades J. NATURAL HISTORY, PATHOGENESIS, AND ETIOLOGY OF THORACIC AORTIC ANEURYSMS AND DISSECTIONS. Cardiology Clinics 1999, 17: 615-635. PMID: 10589336, DOI: 10.1016/s0733-8651(05)70105-3.Peer-Reviewed Original Research
1996
Skeletal Muscle Ventricles in Continuity with the Bloodstream
Ukoha O, Braxton J, Letsou G, Hogan J, Ariyan S, Elefteriades J. Skeletal Muscle Ventricles in Continuity with the Bloodstream. Journal Of Cardiac Surgery 1996, 11: 271-279. PMID: 8902641, DOI: 10.1111/j.1540-8191.1996.tb00050.x.Peer-Reviewed Original ResearchConceptsAverage systolic pressureDegree of augmentationSystolic pressureDiastolic augmentationBlood flowCanine modelEnd-stage congestive heart failureOutflow conduitIntra-aortic balloon pumpStimulation delayCongestive heart failureLatissimus dorsi muscleSkeletal muscle ventriclesSMV ruptureSMV stimulationThoracodorsal nerveTiming of stimulationArterial pressureRespiratory insufficiencyBalloon pumpHeart failureProlonged anticoagulationValved conduitIntraoperative instabilityProsthetic valves
1994
The aortic bodice: A life-saving maneuver
Sanchez J, Elefteriades J, Hammond G. The aortic bodice: A life-saving maneuver. The Annals Of Thoracic Surgery 1994, 58: 252-253. PMID: 8037542, DOI: 10.1016/0003-4975(94)91120-7.Peer-Reviewed Original Research