2001
Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention
Goldstein L, Davies R, Rizzo J, Davila J, Cooperberg M, Shaw R, Kopf G, Elefteriades J. Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention. Journal Of Thoracic And Cardiovascular Surgery 2001, 122: 935-945. PMID: 11689799, DOI: 10.1067/mtc.2001.117276.Peer-Reviewed Original ResearchConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestThoracic aortaCirculatory arrestEmergency operationAge-adjusted survivalAntegrade cerebral perfusionThoracic aortic operationsPrevention of strokeIntensive care unitPostoperative stayAortic atheromaAortic manipulationAortic operationsPostoperative deathsCardiopulmonary bypassCerebral perfusionFemoral perfusionNeurologic consultationCare unitElective operationsHeart bypassThorough debridementOperative reportsLeft heart
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashion
1997
The “pro” point of view
Elefteriades J. The “pro” point of view. Journal Of Cardiothoracic And Vascular Anesthesia 1997, 11: 661-668. PMID: 9263104, DOI: 10.1016/s1053-0770(97)90023-9.Peer-Reviewed Original Research
1996
Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics.
Braxton J, Higgins R, Schwann T, Sanchez J, Dewar M, Kopf G, Hammond G, Letsou G, Elefteriades J. Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics. The Journal Of Heart Valve Disease 1996, 5: 169-73. PMID: 8665010.Peer-Reviewed Original ResearchMeSH KeywordsBlood Loss, SurgicalCardiac Surgical ProceduresCardiopulmonary BypassHeart Valve DiseasesHemodynamicsHumansMitral ValveReoperationRetrospective StudiesThoracotomyConceptsMitral valve surgeryReoperative mitral valve surgeryRight thoracotomy approachThoracotomy approachBlood lossValve surgeryInotropic supportBypass timeThoracotomy patientsRight thoracotomyOperative timeRight antero-lateral thoracotomyUnderwent mitral valve replacementPaO2/FiO2 ratioRedo mitral valve surgeryBioprosthetic valve failureProlonged hospital courseSevere pulmonary dysfunctionSignificant inotropic supportCardiopulmonary bypass timeLength of ICUMitral valve proceduresMitral valve replacementCoronary artery graftsExcessive blood loss
1993
Transesophageal two-dimensional echocardiographic analysis of right ventricular systolic performance indices during coronary artery bypass grafting
Rafferty T, Durkin M, Harris S, Elefteriades J, Hines R, Prokop E, O'Connor T. Transesophageal two-dimensional echocardiographic analysis of right ventricular systolic performance indices during coronary artery bypass grafting. Journal Of Cardiothoracic And Vascular Anesthesia 1993, 7: 160-166. PMID: 8477020, DOI: 10.1016/1053-0770(93)90210-c.Peer-Reviewed Original ResearchConceptsEnd-diastolic volume indexPulmonary artery pressureEnd-diastolic pressureCardiopulmonary bypassCardiac indexRV end-diastolic volume indexSignificant right coronary artery diseaseCoronary artery bypass surgeryRight coronary artery diseaseRV end-diastolic pressurePost-CPB valuesArtery bypass surgeryCoronary artery bypassCoronary artery diseaseMin/m2Two-dimensional echocardiographic analysisML/m2Inotropic supportIntraoperative courseArtery bypassArtery pressureBypass surgeryNitroglycerin infusionArtery diseaseEjection fraction
1992
Transesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent
Rafferty T, Durkin M, Elefteriades J, O’Connor T. Transesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent. Journal Of Thoracic And Cardiovascular Surgery 1992, 104: 637-641. PMID: 1513154, DOI: 10.1016/s0022-5223(19)34729-4.Peer-Reviewed Original ResearchConceptsCrystalloid cardioplegic solutionCardioplegic solutionValve dysfunctionValve integrityEchocardiographic contrast agentsImaging agentVentricular dimensional changesAortic regurgitationEchocardiographic evaluationLeft atriumCardiac dimensionsIntravascular injectionSolution administrationPatientsDysfunctionContrast agentsAgentsEchocardiographyRegurgitationAtriumAdministrationIs Cardiopulmonary Bypass Effective for Treatment of Hypothermic Arrest due to Drowning or Exposure?
Letsou G, Kopf G, Elefteriades J, Carter J, Baldwin J, Hammond G. Is Cardiopulmonary Bypass Effective for Treatment of Hypothermic Arrest due to Drowning or Exposure? JAMA Surgery 1992, 127: 525-528. PMID: 1575622, DOI: 10.1001/archsurg.1992.01420050045005.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassHypothermic arrestMedian sternotomyEmergency hospital admissionsNormal neurologic functionFull cardiopulmonary arrestFreshwater drowningHospital admissionNeurologic functionSinus bradycardiaSuch patientsThree patientsCardiopulmonary arrestFourth patientVentricular fibrillationPatientsBypassSternotomyCore temperatureResuscitationArrestExposureAsystoleBradycardiaDrowningRight Ventricular Assist Devices and the Surgical Treatment of Right Ventricular Failure
Higgins R, Elefteriades J. Right Ventricular Assist Devices and the Surgical Treatment of Right Ventricular Failure. Cardiology Clinics 1992, 10: 185-192. PMID: 1739958, DOI: 10.1016/s0733-8651(18)30262-5.Peer-Reviewed Original ResearchMeSH KeywordsCardiopulmonary BypassCounterpulsationHeart FailureHeart TransplantationHeart-Assist DevicesHumansPulmonary EmbolismVentricular Function, RightConceptsVentricular assist deviceCirculatory supportCardiopulmonary bypassAssist deviceSevere right ventricular dysfunctionRight ventricular assist deviceLong-term circulatory supportRight ventricular dysfunctionRight ventricular failureRight ventricular functionHigh-risk patientsIntraaortic balloon pumpMechanical circulatory supportTreatment of patientsInotropic supportProgressive therapyCardiac transplantationVentricular dysfunctionVentricular failureBiventricular failureBalloon pumpSurgical treatmentVentricular functionVolume statusHigh morbidity
1989
Profound hypothermia and circulatory arrest for aneurysm surgery. Case report.
Chyatte D, Elefteriades J, Kim B. Profound hypothermia and circulatory arrest for aneurysm surgery. Case report. Journal Of Neurosurgery 1989, 70: 489-91. PMID: 2915254, DOI: 10.3171/jns.1989.70.3.0489.Peer-Reviewed Original ResearchConceptsCirculatory arrestClosed chest methodProfound hypothermiaExtracorporeal circulationDirect surgical repairVertebral artery aneurysmSurgical repairArtery aneurysmAneurysm surgeryDirect cannulationRight atriumVascular lesionsFemoral vesselsMost surgeonsHypothermiaArrestPatientsSurgeryCannulationAneurysmsAorta