2024
The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy
Liu M, Dong H, Mazlout A, Wu Y, Kalyanasundaram A, Oshinski J, Sun W, Elefteriades J, Leshnower B, Gleason R. The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy. Computers In Biology And Medicine 2024, 170: 108041. PMID: 38330820, PMCID: PMC10932856, DOI: 10.1016/j.compbiomed.2024.108041.Peer-Reviewed Original ResearchMeSH KeywordsAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationEndovascular ProceduresHumansRetrospective StudiesRisk FactorsTreatment OutcomeConceptsType B aortic dissectionTreated with optimal medical therapyAortic growth rateOptimal medical therapyUncomplicated type B aortic dissectionB aortic dissectionMedical therapyCT scanPatients' long-term survivalType B aortic dissection patientsLong-term outcomesLong-term survivalFailure groupAortic expansionChronic phaseFailure patientsPatientsCT imagesTherapyDissectionStatistical shape modelFailurePrognosisScanningRegression
2023
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchMeSH KeywordsAortaAortic AneurysmAortic Aneurysm, ThoracicAortic DissectionAortic RuptureHumansRetrospective StudiesRisk FactorsUniversitiesConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteria
2009
Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities
Percy A, Widman S, Rizzo JA, Tranquilli M, Elefteriades JA. Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities. The Annals Of Thoracic Surgery 2009, 87: 117-123. PMID: 19101283, DOI: 10.1016/j.athoracsur.2008.10.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCase-Control StudiesCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient SatisfactionPostoperative CarePreoperative CareProbabilityPsychometricsRadiographyReference ValuesRetrospective StudiesRisk AssessmentSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestAortic surgeryCirculatory arrestStudy groupStraight deep hypothermic circulatory arrestYale-New Haven HospitalOpen distal anastomosisThoracic aortic surgeryTotal arch replacementArch replacementCerebral protectionPreoperative statusDistal anastomosisSuch patientsFunctional outcomeControl subjectsPatientsSurgeryControl groupAdverse effectsSignificant differencesCognitive changesDaily activitiesOverall score
2007
What Is the Optimal Management of Late-Presenting Survivors of Acute Type A Aortic Dissection?
Davies RR, Coe MP, Mandapati D, Gallo A, Botta DM, Elefteriades JA, Coady MA. What Is the Optimal Management of Late-Presenting Survivors of Acute Type A Aortic Dissection? The Annals Of Thoracic Surgery 2007, 83: 1593-1602. PMID: 17462364, DOI: 10.1016/j.athoracsur.2006.12.018.Peer-Reviewed Original ResearchConceptsLong-term survivalOperative repairAortic dissectionGroup AAcute Type A Aortic DissectionType A Aortic DissectionImproved long-term survivalOptimal managementExcellent long-term resultsA Aortic DissectionInitial medical managementCongestive heart failureCoronary artery diseaseOnset of symptomsLong-term resultsImmediate operative repairAcute typeSurgical emergencySymptom onsetArtery diseaseHeart failurePulmonary diseaseMedical managementSingle institutionGroup B
2001
Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention
Goldstein L, Davies R, Rizzo J, Davila J, Cooperberg M, Shaw R, Kopf G, Elefteriades J. Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention. Journal Of Thoracic And Cardiovascular Surgery 2001, 122: 935-945. PMID: 11689799, DOI: 10.1067/mtc.2001.117276.Peer-Reviewed Original ResearchConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestThoracic aortaCirculatory arrestEmergency operationAge-adjusted survivalAntegrade cerebral perfusionThoracic aortic operationsPrevention of strokeIntensive care unitPostoperative stayAortic atheromaAortic manipulationAortic operationsPostoperative deathsCardiopulmonary bypassCerebral perfusionFemoral perfusionNeurologic consultationCare unitElective operationsHeart bypassThorough debridementOperative reportsLeft heartSingle-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆
Kim R, Mariconda D, Tellides G, Kopf G, Dewar M, Lin Z, Elefteriades J. Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆. European Journal Of Cardio-Thoracic Surgery 2001, 20: 127-132. PMID: 11423285, DOI: 10.1016/s1010-7940(01)00765-5.Peer-Reviewed Original ResearchConceptsSingle-clamp techniqueCoronary artery bypassPostoperative strokeArtery bypassStroke preventionCerebrovascular accidentSide-biting aortic clampAdverse myocardial effectsCross-clamp timePostoperative adverse eventsPerioperative myocardial infarctionCoronary bypass operationsLogistic regression analysisEmbolic consequencesHospital mortalityAdverse eventsAortic clampMyocardial effectsBypass operationMyocardial infarctionMyocardial protectionClinical practiceClamp techniqueSecond surgeonStroke
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptoms
1999
DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS
Coady M, Rizzo J, Elefteriades J. DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS. Cardiology Clinics 1999, 17: 827-839. PMID: 10589349, DOI: 10.1016/s0733-8651(05)70118-1.Peer-Reviewed Original ResearchConceptsSurgical interventionAcute ascending aortic dissectionAscending aortic dissectionConcomitant aortic insufficiencyIntervention criteriaLarger patient numbersAppropriate clinical careThoracic aortic aneurysmSize criteriaSurgical intervention criteriaOverall physical conditionAortic insufficiencyAdverse eventsAortic dissectionPatient ageAortic sizeOrgan compressionPatient enrollmentPatient numbersAortic aneurysmThoracic aortaSymptomatic stateClinical careClinical experienceLife expectancyManagement of descending aortic dissection
Elefteriades J, Lovoulos C, Coady M, Tellides G, Kopf G, Rizzo J. Management of descending aortic dissection. The Annals Of Thoracic Surgery 1999, 67: 2002-2005. PMID: 10391358, DOI: 10.1016/s0003-4975(99)00428-2.Peer-Reviewed Original ResearchConceptsThoracic aortic diseaseAortic replacementAortic dissectionAortic diseaseVascular occlusionCategory of patientsEarly hospital courseTime of dissectionParaplegia rateAcute dissectionHospital coursePostoperative deathsAcute expansionPatient demographicsConsecutive patientsMultiple complicationsBenign courseMedical managementSpecific complicationsSurgical interventionClinical recordsAortic aneurysmComplicated dissectionFenestration procedureTherapy variesFamilial Patterns of Thoracic Aortic Aneurysms
Coady M, Davies R, Roberts M, Goldstein L, Rogalski M, Rizzo J, Hammond G, Kopf G, Elefteriades J. Familial Patterns of Thoracic Aortic Aneurysms. JAMA Surgery 1999, 134: 361-367. PMID: 10199307, DOI: 10.1001/archsurg.134.4.361.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAortic Aneurysm, ThoracicFemaleHumansMaleMiddle AgedPedigreeRetrospective StudiesConceptsThoracic aortic aneurysmSporadic thoracic aortic aneurysmConcomitant aortic dissectionAortic dissectionAortic aneurysmMarfan syndromeAortic diseaseAutosomal recessive modeFamilial patternMean ageFamily historyRecessive modeCollagen vascular disordersTime of diagnosisThoracic aortic diseaseGenetic factorsNew risk factorsFamily pedigreeConcomitant diseasesRetrospective reviewAortic sizeUniversity HospitalRisk factorsVascular disordersAutosomal dominant modeInterval or Permanent Nonoperative Management of Acute Type A Aortic Dissection
Scholl F, Coady M, Davies R, Rizzo J, Hammond G, Kopf G, Elefteriades J. Interval or Permanent Nonoperative Management of Acute Type A Aortic Dissection. JAMA Surgery 1999, 134: 402-406. PMID: 10199313, DOI: 10.1001/archsurg.134.4.402.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAortic Aneurysm, ThoracicAortic DissectionCohort StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeConceptsAcute Type A Aortic DissectionType A Aortic DissectionA Aortic DissectionAortic dissectionShort-term outcomesOperative candidatesNonoperative managementMedical therapyMedical treatmentAggressive medical therapyImmediate surgical therapyInitial operative treatmentSevere aortic insufficiencyAggressive medical treatmentGroup of patientsShort-term survivalHospital mortalityAcute typeCoronary ischemiaInitial misdiagnosisNonoperative therapySignificant comorbiditiesVascular complicationsAortic insufficiencyDefinitive operation
1998
Procedures for Estimating Growth Rates in Thoracic Aortic Aneurysms
Rizzo J, Coady M, Elefteriades J. Procedures for Estimating Growth Rates in Thoracic Aortic Aneurysms. Journal Of Clinical Epidemiology 1998, 51: 747-754. PMID: 9731923, DOI: 10.1016/s0895-4356(98)00050-x.Peer-Reviewed Original ResearchConceptsTAA growth ratesStatistical problemsStatistical methodsEstimation procedureTAA growthConventional approachesMore reliable resultsInstrumental variable estimationVariable estimationMeasurement errorRate estimatesPrecise estimatesEstimationMeasured growth rateReliable estimatesEstimatesReliable resultsProblemConventional methodsApproachLethal medical conditionErrorPenetrating ulcer of the thoracic aorta: What is it? How do we recognize it? How do we manage it?
Coady M, Rizzo J, Hammond G, Pierce J, Kopf G, Elefteriades J. Penetrating ulcer of the thoracic aorta: What is it? How do we recognize it? How do we manage it? Journal Of Vascular Surgery 1998, 27: 1006-1016. PMID: 9652462, DOI: 10.1016/s0741-5214(98)70003-5.Peer-Reviewed Original ResearchConceptsAortic dissectionOptimal treatmentThoracic aortaNatural historyType AType B aortic dissectionB aortic dissectionClassic aortic dissectionLarger aortic diametersAortic ulcerAtherosclerotic ulcerAortic ruptureClinical featuresInitial diagnosisInitial presentationIntraoperative findingsRetrospective reviewSurgical managementAortic diameterRadiologic signsTomographic scanPathology reportsUlcersPatientsAorta
1996
Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics.
Braxton J, Higgins R, Schwann T, Sanchez J, Dewar M, Kopf G, Hammond G, Letsou G, Elefteriades J. Reoperative mitral valve surgery via right thoracotomy: decreased blood loss and improved hemodynamics. The Journal Of Heart Valve Disease 1996, 5: 169-73. PMID: 8665010.Peer-Reviewed Original ResearchConceptsMitral valve surgeryReoperative mitral valve surgeryRight thoracotomy approachThoracotomy approachBlood lossValve surgeryInotropic supportBypass timeThoracotomy patientsRight thoracotomyOperative timeRight antero-lateral thoracotomyUnderwent mitral valve replacementPaO2/FiO2 ratioRedo mitral valve surgeryBioprosthetic valve failureProlonged hospital courseSevere pulmonary dysfunctionSignificant inotropic supportCardiopulmonary bypass timeLength of ICUMitral valve proceduresMitral valve replacementCoronary artery graftsExcessive blood loss
1990
Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias
Elefteriades J, Biblo L, Batsford W, Rosenfeld L, Henthorn R, Carlson M, Waldo A, Hsu J, Geha A. Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias. The Annals Of Thoracic Surgery 1990, 49: 94-100. PMID: 2297279, DOI: 10.1016/0003-4975(90)90362-a.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorResection groupThirty-day mortalityCoronary artery bypassMalignant ventricular tachyarrhythmiasIntractable ventricular arrhythmiasImplantable cardioverter defibrillatorAICD placementArtery bypassSurgical treatmentEndocardial resectionVentricular arrhythmiasVentricular tachyarrhythmiasAntiarrhythmic agentsSudden deathCardioverter defibrillatorResectionMortality figuresPatientsEffective interventionsGreatest overall benefitSurvivalGroupOverall benefitValuable alternative
1989
Mild mitral insufficiency is a marker of impaired left ventricular performance in aortic stenosis
Schulman D, Remetz M, Elefteriades J, Frances C. Mild mitral insufficiency is a marker of impaired left ventricular performance in aortic stenosis. Journal Of The American College Of Cardiology 1989, 13: 796-801. PMID: 2926033, DOI: 10.1016/0735-1097(89)90218-0.Peer-Reviewed Original ResearchConceptsAortic stenosisEjection fractionGroup 2Mitral insufficiencyGroup 1Ventricular performanceEnd-systolic volume index ratioControl groupEnd-systolic volume indexSignificant coronary artery diseaseEnd-systolic wall stressImpaired left ventricular performanceGroup 2 patientsMild mitral insufficiencyPure aortic stenosisAortic valve replacementAortic valve areaCoronary artery diseaseLeft ventricular functionEnd-systolic stressLeft ventricular performanceWall stressCardiac indexValve replacementArtery disease