2023
KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Velasco J, Li Y, Ziganshin B, Zafar M, Rizzo J, Ma D, Zang H, Kalyanasundaram A, Elefteriades J. KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection. Genes 2023, 14: 252. PMID: 36833179, PMCID: PMC9956195, DOI: 10.3390/genes14020252.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dissectionOdds ratioVariant statusArg allele carriersThoracic aortic dissectionOccurrence of ADAortic sizeArg alleleMarked adverse impactTAA patientsAortic aneurysmClinical assessmentSurgical decisionAllele carriersIncrease riskVariant patientsArg carriersPilot studyDissectionImportant intracellular functionsConfirmatory findingsPatientsAneurysmsPresent study
2018
Genetic testing to modulate when to operate in thoracic aortic disease
Kostiuk V, Brownstein A, Ziganshin B, Elefteriades J. Genetic testing to modulate when to operate in thoracic aortic disease. Journal Of Visualized Surgery 2018, 4: 193-193. DOI: 10.21037/jovs.2018.07.14.Peer-Reviewed Original ResearchMolecular geneticsThoracic aortic aneurysmSurgical treatment optionsNon-syndromic thoracic aortic aneurysmsMolecular profilingSmooth muscle cell functionFamilial thoracic aortic aneurysmsMultiple genesSpecific genesMuscle cell functionTAA patientsTreatment optionsExtracellular matrixCell functionThoracic aortic diseaseGenesPositive family historyGeneticsProfilingTAA developmentAortic diseaseAortic aneurysmCurrent classificationDisease progressionFamily history“Getting beyond diameter”: when to replace the aorta?
Tanweer M, Zafar M, Saeyeldin A, Gryaznov A, Puddifant A, Erben Y, Ziganshin B, Elefteriades J. “Getting beyond diameter”: when to replace the aorta? Journal Of Visualized Surgery 2018, 4: 124-124. DOI: 10.21037/jovs.2018.06.04.Peer-Reviewed Original ResearchAortic sizeThoracic aortic aneurysm patientsProgression of TAAAortic aneurysm patientsTimely surgical interventionBody surface areaProphylactic surgical repairSpecific genetic mutationsUse of biomarkersAdvanced imaging techniquesAortic surgeryAortic dissectionSurgical treatmentCatastrophic complicationSurgical repairPrognostic importancePrognostic significanceSurgical interventionAneurysm patientsTAA patientsPatient heightDisease progressionFamily historyFemale genderAnatomical aberrations
2007
Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm
Wang Y, Barbacioru CC, Shiffman D, Balasubramanian S, Iakoubova O, Tranquilli M, Albornoz G, Blake J, Mehmet NN, Ngadimo D, Poulter K, Chan F, Samaha RR, Elefteriades JA. Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm. PLOS ONE 2007, 2: e1050. PMID: 17940614, PMCID: PMC2002514, DOI: 10.1371/journal.pone.0001050.Peer-Reviewed Original ResearchMeSH KeywordsAortic Aneurysm, ThoracicCase-Control StudiesCluster AnalysisFalse Positive ReactionsGene ExpressionGene Expression ProfilingGene Expression RegulationGenome, HumanHumansOligonucleotide Array Sequence AnalysisReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTranscription, GeneticConceptsPeripheral blood cellsGene expression signaturesAortic aneurysmPeripheral bloodTAA patientsExpression signaturesBlood cellsBlood-based gene expression testAdverse clinical outcomesElective surgical repairThoracic aortic aneurysmPeripheral blood samplesPotential diagnostic markerPotential signature genesClassifier genesGene expression testDistinct gene expression signaturesSurgical repairClinical outcomesReal-time PCRBlood samplesRisk individualsTherapeutic interventionsDisease statusHigh mortality