2023
Bicuspid aortopathy does not require earlier surgical intervention
Zafar M, Wu J, Vinholo T, Li Y, Papanikolaou D, Ellauzi H, Ostberg N, Kalyanasundaram A, Kalogerakos P, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Bicuspid aortopathy does not require earlier surgical intervention. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 760-769.e4. PMID: 37088130, DOI: 10.1016/j.jtcvs.2023.04.017.Peer-Reviewed Original ResearchBicuspid aortic valveAdverse aortic eventsEvent-free survivalAortic eventsAortic sizeAortic diameterAortic growth rateEarly surgical interventionLong-term complicationsRisk of complicationsThoracic aortic aneurysmAortic deathComplication rateSurgical repairOperative repairProphylactic surgerySurgical interventionAortic aneurysmAortic valveSurgical correctionBicuspid aortopathyRelative riskExpert centersTAV-ATAAPatientsAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesNonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta
Elefteriades J, Ziganshin B, Zafar M. Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta. Aorta 2023, 11: 071-086. PMID: 37172942, PMCID: PMC10232037, DOI: 10.1055/s-0043-1766114.Peer-Reviewed Original ResearchThoracic aortic aneurysmSurgical interventionAortic eventsAortic dissectionSubsternal chest painBlood pressure elevationBicuspid aortic valveAfferent neural pathwaysAscending thoracic aortaEmission Tomography ImagingPositron emission tomography (PET) imagingAortic stressAscending aneurysmAortic surgeryChest painEarly surgerySpecific genetic aberrationsHigh rupture riskMural thickeningRoot dilatationBicuspid valvePressure elevationAneurysm patientsAortic aneurysmAortic riskFate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteriaFull calcium jacket: Conservative management of a traumatic aortic injury
Tripathi R, Ellauzi H, Zafar M, Ziganshin B, Elefteriades J. Full calcium jacket: Conservative management of a traumatic aortic injury. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101132. PMID: 37139352, PMCID: PMC10149390, DOI: 10.1016/j.jvscit.2023.101132.Peer-Reviewed Original Research
2019
Mechanics of the Thoracic Aortic Wall
Ziganshin B, Elefteriades J. Mechanics of the Thoracic Aortic Wall. 2019, 149-162. DOI: 10.1007/978-3-7091-4874-7_10.Peer-Reviewed Original Research
2018
“Getting beyond diameter”: when to replace the aorta?
Tanweer M, Zafar M, Saeyeldin A, Gryaznov A, Puddifant A, Erben Y, Ziganshin B, Elefteriades J. “Getting beyond diameter”: when to replace the aorta? Journal Of Visualized Surgery 2018, 4: 124-124. DOI: 10.21037/jovs.2018.06.04.Peer-Reviewed Original ResearchAortic sizeThoracic aortic aneurysm patientsProgression of TAAAortic aneurysm patientsTimely surgical interventionBody surface areaProphylactic surgical repairSpecific genetic mutationsUse of biomarkersAdvanced imaging techniquesAortic surgeryAortic dissectionSurgical treatmentCatastrophic complicationSurgical repairPrognostic importancePrognostic significanceSurgical interventionAneurysm patientsTAA patientsPatient heightDisease progressionFamily historyFemale genderAnatomical aberrationsTime to Move to Earlier Intervention for Thoracic Aortic Aneurysm?
Gryaznov A, Ziganshin B, Elefteriades J. Time to Move to Earlier Intervention for Thoracic Aortic Aneurysm? Structural Heart 2018, 2: 10-22. DOI: 10.1080/24748706.2017.1404664.Peer-Reviewed Original ResearchThoracic aortic aneurysmBody surface areaAortic aneurysmMost life-threatening complicationsAortic growth rateEarly prophylactic interventionAcute aortic dissectionLife-threatening complicationsPatient/yearProphylactic surgical interventionSpecific genetic aberrationsAortic dissectionAortic sizeAortic diseaseCurrent gold standardSurgical interventionPatient heightProphylactic interventionsThoracic aortaAneurysm diseaseCommon causeFamily historyEarly diagnosisEarly interventionGenetic aberrationsChapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic
Zafar M, Peterss S, Ziganshin B, Elefteriades J. Chapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic. 2018, 41-59. DOI: 10.1016/b978-0-12-809979-7.00003-1.Peer-Reviewed Original ResearchChronic stateUncomplicated acute type B dissectionAcute type B dissectionAcute Stanford typeType B dissectionEarly surgical interventionTreatment of choiceChronic dissectionB dissectionStanford typeAortic dissectionMedical therapyAortic diseaseSurgical interventionDissectionAortaTemporal courseHistologyMorphological changesAcuteChronicHistopathologyTherapyDiseaseProgressionChapter 22 Current Status of Medical Therapy of Thoracic Aortic Aneurysm and Dissection
Percy A, Mukherjee S, Ziganshin B, Elefteriades J. Chapter 22 Current Status of Medical Therapy of Thoracic Aortic Aneurysm and Dissection. 2018, 235-249. DOI: 10.1016/b978-0-12-809979-7.00022-5.Peer-Reviewed Original ResearchThoracic aortic aneurysmAortic aneurysmMost thoracic aortic aneurysmsAngiotensin receptor blockersClasses of medicationsAortic aneurysm developmentRelevant clinical endpointsAortic aneurysm expansionAsymptomatic patientsLifestyle modificationReceptor blockersMedical therapySurgical repairAortic catastropheClinical evidencePathophysiologic pathwaysSurgical interventionPathophysiologic basisTreatment modalitiesAneurysm expansionClinical endpointsClinical trialsCurrent guidelinesAneurysm formationClinical studies
1999
DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS
Coady M, Rizzo J, Elefteriades J. DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS. Cardiology Clinics 1999, 17: 827-839. PMID: 10589349, DOI: 10.1016/s0733-8651(05)70118-1.Peer-Reviewed Original ResearchConceptsSurgical interventionAcute ascending aortic dissectionAscending aortic dissectionConcomitant aortic insufficiencyIntervention criteriaLarger patient numbersAppropriate clinical careThoracic aortic aneurysmSize criteriaSurgical intervention criteriaOverall physical conditionAortic insufficiencyAdverse eventsAortic dissectionPatient ageAortic sizeOrgan compressionPatient enrollmentPatient numbersAortic aneurysmThoracic aortaSymptomatic stateClinical careClinical experienceLife expectancySurgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications
Coady M, Rizzo J, Hammond G, Kopf G, Elefteriades J. Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications. The Annals Of Thoracic Surgery 1999, 67: 1922-1926. PMID: 10391339, DOI: 10.1016/s0003-4975(99)00431-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmDevastating complicationAortic growth rateComplications of ruptureIncidence of dissectionTime of complicationsRisk of dissectionMultivariable regression analysisMedian sizeSurgical intervention criteriaTime of dissectionAcute dissectionElective resectionPerioperative complicationsInitial presentationSurgical interventionRisk factorsThoracic aortaAneurysm sizeComplicationsTime of ruptureYale University SchoolLower mortalityAneurysmsManagement of descending aortic dissection
Elefteriades J, Lovoulos C, Coady M, Tellides G, Kopf G, Rizzo J. Management of descending aortic dissection. The Annals Of Thoracic Surgery 1999, 67: 2002-2005. PMID: 10391358, DOI: 10.1016/s0003-4975(99)00428-2.Peer-Reviewed Original ResearchConceptsThoracic aortic diseaseAortic replacementAortic dissectionAortic diseaseVascular occlusionCategory of patientsEarly hospital courseTime of dissectionParaplegia rateAcute dissectionHospital coursePostoperative deathsAcute expansionPatient demographicsConsecutive patientsMultiple complicationsBenign courseMedical managementSpecific complicationsSurgical interventionClinical recordsAortic aneurysmComplicated dissectionFenestration procedureTherapy varies
1997
Multimodality serial follow-up of thoracic aortic aneurysms
Rizzo J, Darr U, Fischer M, Johnson K, Finkle J, Gusberg R, Kopf G, Abbott T, Shevchenko I, Elefteriades J. Multimodality serial follow-up of thoracic aortic aneurysms. International Journal Of Angiology 1997, 6: 153-156. DOI: 10.1007/bf01616173.Peer-Reviewed Original ResearchThoracic aortaAortic dissectionMale patientsLarge aneurysmsMultivariate risk factor analysisYale-New Haven HospitalThoraco-abdominal aortaThoracic aortic aneurysmThoracic aorta aneurysmRisk factor analysisDiagnostic imaging testsTime of dissectionAortic expansionSurgical interventionAortic aneurysmAorta aneurysmImaging testsTime of rupturePatientsAneurysmsAortaImaging studiesDissectionLong-term survival prospectsLower survivalWhat is the appropriate size criterion for resection of thoracic aortic aneurysms?
Coady M, Rizzo J, Hammond G, Mandapati D, Darr U, Kopf G, Elefteriades J. What is the appropriate size criterion for resection of thoracic aortic aneurysms? Journal Of Thoracic And Cardiovascular Surgery 1997, 113: 476-491. PMID: 9081092, DOI: 10.1016/s0022-5223(97)70360-x.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmIncidence of dissectionTime of complicationsMultivariable regression analysisMedian sizeAppropriate size criterionTime of dissectionAcute dissectionElective resectionPerioperative complicationsDevastating complicationOverall survivalAortic dissectionInitial presentationElective operationsSurgical interventionRisk factorsThoracic aortaAneurysm sizeTime of rupturePatientsYale University SchoolAneurysmsLower mortality