2022
Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation
Dong H, Liu M, Lou X, Leshnower B, Sun W, Ziganshin B, Zafar M, Elefteriades J. Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation. Applications In Engineering Science 2022, 10: 100101. DOI: 10.1016/j.apples.2022.100101.Peer-Reviewed Original ResearchThoracic aortic dissectionAortic dissectionAortic tissueDissection eventsBicuspid aortic valveUnderlying genetic abnormalitiesHuman aortic tissueHypertensive episodesAortic arch morphologyAortic valveAdvanced ageTissue injuryConnective tissue ingrowthAged animalsAortic wallInciting factorsGenetic abnormalitiesClinical contextArch morphologyDissectionDissected tissuesTissueResponseTissue ingrowthInjuryThe Genetics of Inheritable Aortic Diseases
Kalyanasundaram A, Elefteriades J. The Genetics of Inheritable Aortic Diseases. Current Cardiovascular Risk Reports 2022, 16: 13-24. DOI: 10.1007/s12170-022-00687-x.Peer-Reviewed Original ResearchAbdominal aortic aneurysmRisk factorsAortic diseaseAortic aneurysmPatient outcomesGene variantsTraditional cardiovascular risk factorsBetter long-term survivalCV risk factorsDevelopment of TAADCardiovascular risk factorsBetter patient outcomesLong-term survivalGeneral risk factorsPurpose of ReviewOverTGF-β pathwayEarly surgeryLipid metabolism pathwaysDefinitive treatmentAneurysmal diseaseAortic diameterProphylactic surgeryAggressive casesPatient-specific guidelinesAortic wall
2021
A probabilistic and anisotropic failure metric for ascending thoracic aortic aneurysm risk assessment
Liu M, Liang L, Zou Q, Ismail Y, Lou X, Iannucci G, Chen E, Leshnower B, Elefteriades J, Sun W. A probabilistic and anisotropic failure metric for ascending thoracic aortic aneurysm risk assessment. Journal Of The Mechanics And Physics Of Solids 2021, 155: 104539. DOI: 10.1016/j.jmps.2021.104539.Peer-Reviewed Original ResearchATAA patientsAortic wallAortic tissue samplesThoracic aortic aneurysmAortic aneurysmAneurysm rupturePatientsRisk assessmentTissue samplesCharacteristic curveFailure metricsTsai-Hill failure criterionCT imagesRiskTensile failure testsMaximum principal stressRupture risk assessmentPrevious studiesAssessment
2019
Mechanics of the Thoracic Aortic Wall
Ziganshin B, Elefteriades J. Mechanics of the Thoracic Aortic Wall. 2019, 149-162. DOI: 10.1007/978-3-7091-4874-7_10.Peer-Reviewed Original Research
2017
Mechanisms of Disease and Natural History
Ziganshin B, Elefteriades J. Mechanisms of Disease and Natural History. 2017, 19-43. DOI: 10.1007/978-3-319-15192-2_2.Peer-Reviewed Original ResearchAortic diseaseNatural historyEndovascular treatment optionsThoracic aortic diseaseClassic open surgeryDiseased aortic wallEvidence-based criteriaMechanisms of diseaseAortic pathologyAortic ruptureLethal complicationOpen surgeryProphylactic treatmentEndovascular interventionTreatment optionsIndividual patientsAortic wallPersonalized managementMechanisms of developmentDiseasePatientsSuch treatmentTreatmentCurrent understandingComplications
2006
Matrix Metalloproteinases in Thoracic Aortic Aneurysm Disease
Botta D, Elefteriades J. Matrix Metalloproteinases in Thoracic Aortic Aneurysm Disease. International Journal Of Angiology 2006, 15: 1-8. DOI: 10.1007/s00547-006-2080-z.Peer-Reviewed Original ResearchAortic aneurysmMatrix metalloproteinasesThoracic aortic aneurysm diseaseAneurysmal aortic segmentsThoracic aortic aneurysmAortic aneurysm diseaseDiseased aortic wallPharmacologic therapySerum levelsAneurysm diseaseAortic segmentsMMP-9Aortic wallClinical monitoringMMP-1Tissue levelsAneurysmsMetalloproteinasesMMPsPivotal roleProteolytic enzymesSite of synthesisPathophysiologyTherapyDiseaseMatrix metalloproteinases in thoracic aortic aneurysm disease
Botta D, Elefteriades J. Matrix metalloproteinases in thoracic aortic aneurysm disease. International Journal Of Angiology 2006, 1-8. DOI: 10.1055/s-0031-1276527.Peer-Reviewed Original ResearchAortic aneurysmMatrix metalloproteinasesThoracic aortic aneurysm diseaseAneurysmal aortic segmentsThoracic aortic aneurysmAortic aneurysm diseaseDiseased aortic wallPharmacologic therapySerum levelsAneurysm diseaseAortic segmentsMMP-9Aortic wallClinical monitoringMMP-1Tissue levelsAneurysmsMetalloproteinasesMMPsPivotal roleProteolytic enzymesSite of synthesisPathophysiologyTherapyDisease
2005
Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta
Koullias G, Modak R, Tranquilli M, Korkolis DP, Barash P, Elefteriades JA. Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta. Journal Of Thoracic And Cardiovascular Surgery 2005, 130: 677.e1-677.e9. PMID: 16153912, DOI: 10.1016/j.jtcvs.2005.02.052.Peer-Reviewed Original ResearchConceptsMechanical characteristicsMechanical deteriorationHuman ascending aortaAortic aneurysmAortic wall stressNormal aortaAneurysmal aortaAortic distensibilityAscending aortaMalignant behaviorAortic wallWall stressMaximal tensile strengthMechanical propertiesCoronary artery bypassTensile strengthTime of surgeryAortic wall thicknessAscending Aortic AneurysmMalignant clinical behaviorElastic modulusHuman ascending aortic aneurysmsEngineering analysisAneurysmal aortic wallMechanical substrate