2020
Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use
Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.Peer-Reviewed Original ResearchConceptsCannabis useUrine samplesLoss of appetiteMinor cannabinoidsRapid LC-MS/MSDronabinol groupDronabinol therapyDronabinol useSevere nauseaPain managementPositive subjectsNormal controlsTherapeutic potentialProspective sampleClinical urine samplesCancer chemotherapySpecific populationsCannabisCannabinoidsMetabolite concentrationsDronabinolLC-MS/MSNegative controlDetection of cannabisCannabidiol
2005
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Roberts JD, Gennings C, Shih M. Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. European Journal Of Pharmacology 2005, 530: 54-58. PMID: 16375890, DOI: 10.1016/j.ejphar.2005.11.036.Peer-Reviewed Original ResearchConceptsExperimental pain modelsAnalgesic interactionPain modelVisual analog scaleFinding of synergyAffective responsesAffective componentsAffective aspectsAnalgesic effectAnalog scaleExperimental painNormal volunteersCrossover designMorphinePainSensory responsesPlaceboThermal stimuliSignificant interactionTHCSignificant effectFuture studiesSubjectsAnalgesiaAnalgesics