2000
Pharmacokinetic and pharmacodynamic evaluation of the glycinamide ribonucleotide formyltransferase inhibitor AG2034.
McLeod HL, Cassidy J, Powrie RH, Priest DG, Zorbas MA, Synold TW, Shibata S, Spicer D, Bissett D, Pithavala YK, Collier MA, Paradiso LJ, Roberts JD. Pharmacokinetic and pharmacodynamic evaluation of the glycinamide ribonucleotide formyltransferase inhibitor AG2034. Clinical Cancer Research 2000, 6: 2677-84. PMID: 10914709.Peer-Reviewed Original ResearchConceptsGlycinamide ribonucleotide formyltransferaseCourse 1Systemic clearanceGrade III/IV toxicityGrade II toxicityMin/m2Rapid systemic clearanceVolume of distributionEvaluable patientsSystemic exposurePharmacodynamic evaluationClinical centersBolus injectionPharmacokinetic approachBlood samplesPatient toxicityPatientsElimination patternReproducible ELISAAG2034Course 3Phase IAnticancer agentsPurine synthesis pathwayDe novo purine synthesis pathway
1999
Chemistry and Biology of Multifunctional DNA Binding Agents
Farrell N, Qu Y, Roberts J. Chemistry and Biology of Multifunctional DNA Binding Agents. Topics In Biological Inorganic Chemistry 1999, 99-115. DOI: 10.1007/978-3-662-03815-4_4.Peer-Reviewed Original Research
1989
Interaction of novel bis(platinum) complexes with DNA
Roberts J, Van Houten B, Qu Y, Farrell N. Interaction of novel bis(platinum) complexes with DNA. Nucleic Acids Research 1989, 17: 9719-9733. PMID: 2690006, PMCID: PMC335209, DOI: 10.1093/nar/17.23.9719.Peer-Reviewed Original Research