2022
Adherence to Guidelines in Heart Failure, Is It Valid for Elderly Patients?
Khoury J, Ghersin I, Braun E, Elias A, Aronson D, Azzam Z, Bahouth F. Adherence to Guidelines in Heart Failure, Is It Valid for Elderly Patients? Israel Medical Association Journal 2022, 24: 757-762. PMID: 36436045.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureAngiotensin receptor blockersPatients 80 yearsEjection fractionHeart failureMedicine groupSingle-center retrospective studyDecompensated heart failureReduced ejection fractionLarge prospective studiesRandomized clinical trialsOlder adult populationGDMT groupMineralocorticoid antagonistsCause mortalityReceptor blockersValue of guidelinesElderly patientsHospital dischargeOlder patientsYounger patientsMedical therapyPrimary outcomeProspective studyRetrospective study
2021
The prognostic value of heart rate at discharge in acute decompensation of heart failure with reduced ejection fraction
Bahouth F, Elias A, Ghersin I, Khoury E, Bar O, Sholy H, Khoury J, Azzam Z. The prognostic value of heart rate at discharge in acute decompensation of heart failure with reduced ejection fraction. ESC Heart Failure 2021, 9: 585-594. PMID: 34821080, PMCID: PMC8788061, DOI: 10.1002/ehf2.13710.Peer-Reviewed Original ResearchConceptsReduced ejection fractionHeart rateHeart failureHazard ratioEjection fractionPrognostic valueTarget doseMortality rateChronic stable heart failureBeta-blocker dosageHeart failure settingAdjusted hazard ratioStable heart failureDay mortality rateSingle-center studyRetrospective observational studyYear mortality rateElevated heart rateLower heart rateHR 70Acute decompensationCause mortalityLaboratory variablesYear mortalityCox regression
2020
SOFA score and short-term mortality in acute decompensated heart failure
Elias A, Agbarieh R, Saliba W, Khoury J, Bahouth F, Nashashibi J, Azzam Z. SOFA score and short-term mortality in acute decompensated heart failure. Scientific Reports 2020, 10: 20802. PMID: 33257739, PMCID: PMC7705654, DOI: 10.1038/s41598-020-77967-2.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureSequential Organ Function Assessment (SOFA) scoreShort-term mortalityDecompensated heart failureSOFA scoreHigh-risk patientsHospital mortalityRisk patientsHeart failureLife-threatening conditionCurve (AUC) of receiverFirst hospitalizationPrimary diagnosisRisk scorePatientsMortalityAssessment scoresStrict monitoringExcellent scoresCharacteristic curveHospitalizationScoresGood predictive accuracyProper managementSepsis
2019
Blood urea nitrogen variation upon admission and at discharge in patients with heart failure
Khoury J, Bahouth F, Stabholz Y, Elias A, Mashiach T, Aronson D, Azzam Z. Blood urea nitrogen variation upon admission and at discharge in patients with heart failure. ESC Heart Failure 2019, 6: 809-816. PMID: 31199082, PMCID: PMC6676277, DOI: 10.1002/ehf2.12471.Peer-Reviewed Original ResearchConceptsBlood urea nitrogenDay mortality rateHeart failureHigher BUN levelsPrognostic predictorBUN levelsMortality rateAcute decompensated heart failureDecompensated heart failureLong-term mortalityBrain natriuretic peptideGlomerular filtration rateShort-term mortalityLack of improvementBUN changeDay mortalityHospital stayCreatinine levelsFirst hospitalizationFirst admissionWorse prognosisMean ageNatriuretic peptidePrognostic valueRetrospective study
2017
The prognostic value of brain natriuretic peptide (BNP) in non-cardiac patients with sepsis, ultra-long follow-up
Khoury J, Arow M, Elias A, Makhoul B, Berger G, Kaplan M, Mashiach T, Ismael-Badarneh R, Aronson D, Azzam Z. The prognostic value of brain natriuretic peptide (BNP) in non-cardiac patients with sepsis, ultra-long follow-up. Journal Of Critical Care 2017, 42: 117-122. PMID: 28719839, DOI: 10.1016/j.jcrc.2017.07.009.Peer-Reviewed Original ResearchConceptsBrain natriuretic peptideLong-term mortalityBNP levelsElevated brain natriuretic peptide levelsRole of BNPBrain natriuretic peptide levelsOrgan Failure Assessment scoreNatriuretic peptide levelsNon-cardiac patientsStrong independent predictorIncidence of morbidityLow-risk groupLong-term survivalMultivariate analysis modelHospital mortalityIndex hospitalizationCritical illnessHeart failureIndependent predictorsSeptic shockNatriuretic peptideOutcome predictorsPrognostic predictorPrognostic valueMultifactorial syndrome