2018
Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
Jiao J, González Á, Stevenson H, Gagea M, Sugimoto H, Kalluri R, Beretta L. Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. Experimental & Molecular Medicine 2018, 50: e422-e422. PMID: 29303514, PMCID: PMC5992984, DOI: 10.1038/emm.2017.175.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell DifferentiationGene Expression Regulation, NeoplasticHepatitisHepatocytesLiver NeoplasmsLiver Neoplasms, ExperimentalMice, KnockoutMice, TransgenicNeoplastic Stem CellsNon-alcoholic Fatty Liver DiseasePTEN PhosphohydrolaseS100 Calcium-Binding Protein A4Stromal CellsConceptsDepletion of S100A4Hepatocellular carcinomaMouse modelCalcium-binding protein S100A4Stromal cellsStemness phenotypeDevelopment of HCCOval cell hyperplasiaReduction of inflammationStemness propertiesCell stemness propertiesNew mouse modelStem cell-like phenotypeViral thymidine kinaseCell-like phenotypeLiver diseaseCell hyperplasiaPoor prognosisGanciclovir injectionsNAS scoreAdjacent liverGastric cancerHCC developmentProtein S100A4Hepatic deletion
2015
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Zhang J, Jiao J, Cermelli S, Muir K, Jung K, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Research 2015, 75: 1859-1867. PMID: 25769721, PMCID: PMC4603420, DOI: 10.1158/0008-5472.can-14-1254.Peer-Reviewed Original ResearchConceptsCancer-associated stromal cellsLiver fibrosisMiR-21Liver cancerProgenitor cellsStromal cellsTumor developmentAssociated liver fibrosisPrevents tumor developmentLiver tumor growthLiver progenitor cellsPreclinical evidenceIntrahepatic cholangiocarcinomaPoor prognosisChemopreventive targetHepatocellular carcinomaHepatic deletionNotch2 inhibitionTumor growthMalignant developmentFibrosisInducing ApoptosisIntegrin αvCancerCell survival