1994
Regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Localization of an intron EBV-responsive enhancer and characterization of its cognate GC-box binding factors.
Lacy J, Roth G, Shieh B. Regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Localization of an intron EBV-responsive enhancer and characterization of its cognate GC-box binding factors. The Journal Of Immunology 1994, 153: 5537-48. PMID: 7989755, DOI: 10.4049/jimmunol.153.12.5537.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCell LineCell Line, TransformedCell Transformation, ViralChloramphenicol O-AcetyltransferaseDNA-Binding ProteinsElectrophoresisEnhancer Elements, GeneticGene Expression RegulationGenes, ReporterHerpesvirus 4, HumanHumansIntronsMolecular Sequence DataPhosphorylationReceptors, IgETransfectionUltraviolet RaysEpstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells.
Roth G, Curiel T, Lacy J. Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells. Blood 1994, 84: 582-7. PMID: 8025284, DOI: 10.1182/blood.v84.2.582.bloodjournal842582.Peer-Reviewed Original ResearchConceptsEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus-immortalized B cellsEpstein-Barr virus nuclear antigen 1EBV-negative cellsLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cellsViral proteinsProliferation
1991
Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein
Lacy J, Bartiss A, Coleman D. Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein. Virus Research 1991, 20: 85-96. PMID: 1656626, DOI: 10.1016/0168-1702(91)90063-2.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, ViralCytosolHerpesvirus 4, HumanHumansLymphoma, B-CellNeoplasm ProteinsPhosphoproteinsPhosphorylationTumor Cells, CulturedTyrosineConceptsEpstein-Barr virusB cellsHuman B cellsB-cell lymphoma linePresence of EBVLymphoma linesProtein tyrosine phosphorylationEBV infectionHuman B cell lymphoma lineTyrosine phosphorylationB lymphocytesImmortalized lymphoblastoid cellsBiochemical changesLymphoblastoid cellsInfectionEndogenous tyrosine kinasesContinuous proliferationCytosolic proteinsTyrosine kinaseVirusCellsPhosphorylationPhosphotyrosine antibodiesLymphocytesProtein
1989
Post-transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein-Barr virus.
Lacy J, Summers W, Summers W. Post-transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein-Barr virus. The EMBO Journal 1989, 8: 1973-80. PMID: 2551670, PMCID: PMC401064, DOI: 10.1002/j.1460-2075.1989.tb03603.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cell linesBJAB cellsNegative Burkitt lymphoma linesPresence of EBVLymphoma linesBurkitt lymphoma linesCell linesNormal human B cellsHuman B cell linesHuman B cellsMYC mRNAEBV genomeVitro infectionMyc transcriptsB cellsEBVLymphoblastoid linesMYC expressionVirusMechanism of deregulationCellsPost-transcriptional mechanismsMYC