1993
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
Rupprecht H, Sukhatme V, Lacy J, Sterzel R, Coleman D. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. American Journal Of Physiology 1993, 265: f351-f360. PMID: 8214093, DOI: 10.1152/ajprenal.1993.265.3.f351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA-Binding ProteinsEarly Growth Response Protein 1Gene ExpressionGlomerular MesangiumImmediate-Early ProteinsMolecular Sequence DataNuclear ProteinsOligonucleotide ProbesPhosphorylationPlatelet-Derived Growth FactorPromoter Regions, GeneticRatsSerum Response FactorTranscription FactorsTranscription, GeneticTyrosineConceptsPlatelet-derived growth factorPDGF stimulationElectrophoretic mobility shift assaysNuclear run-off assaysPromoter deletion analysisEgr-1 transcriptionEarly growth response gene-1Serum response elementUpstream serum response elementsProtein tyrosine phosphorylationMobility shift assaysRun-off assaysResponse gene-1Egr-1 inductionEgr-1 mRNAEgr-1 expressionImmediate early genesTranscriptional inductionDeletion analysisTyrosine phosphorylationShift assaysTranscriptional levelConsensus sequenceTranscription rateGene expression
1992
Transcriptional regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Identification of EBV-responsive regulatory elements in intron 1.
Lacy J, Rudnick H. Transcriptional regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Identification of EBV-responsive regulatory elements in intron 1. The Journal Of Immunology 1992, 148: 1554-60. PMID: 1311350, DOI: 10.4049/jimmunol.148.5.1554.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, B-LymphocyteAntigens, ViralBase SequenceChloramphenicol O-AcetyltransferaseEnhancer Elements, GeneticEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansImmunoglobulin EIntronsMolecular Sequence DataReceptors, FcReceptors, IgERNA, MessengerTranscription, GeneticConceptsRegulatory elementsTranscriptional activationSpecific DNA-protein complexesIntron 1DNA-protein complexesMaintenance of immortalizationTranscriptional regulatory elementsMobility shift assaysReporter gene assayNuclear runoff analysisAdjacent flanking regionsTranscriptional regulationLymphoma linesIntron sequencesNuclear proteinsShift assaysFirst intronEnhancer activityHeterologous promoterReporter geneFlanking regionsEnhancer elementsMolecular mechanismsGene assayGenes
1989
Post‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus.
Lacy J, Summers W, Summers W. Post‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus. The EMBO Journal 1989, 8: 1973-1980. PMID: 2551670, PMCID: PMC401064, DOI: 10.1002/j.1460-2075.1989.tb03603.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cell linesBJAB cellsNegative Burkitt lymphoma linesPresence of EBVLymphoma linesBurkitt lymphoma linesCell linesNormal human B cellsHuman B cell linesHuman B cellsMYC mRNAEBV genomeVitro infectionMyc transcriptsB cellsEBVLymphoblastoid linesMYC expressionVirusMechanism of deregulationCellsPost-transcriptional mechanismsMYC