2023
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease
Sayed A, Assis D, Silveira M, Deng Y, Ciarleglio M, Gaidos J, Proctor D, Al-Bawardy B. Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease. European Journal Of Gastroenterology & Hepatology 2023, 35: 270-274. PMID: 36708297, DOI: 10.1097/meg.0000000000002510.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisInflammatory bowel diseasePSC-IBDEndoscopic healingTherapy groupAdvanced therapiesClinical remissionBowel diseaseAcute ascending cholangitisRate of cholangitisSmall bowel involvementThird of patientsAscending cholangitisSclerosing cholangitisAdult patientsBowel involvementSecondary outcomesMedian agePrimary outcomeRetrospective studyHigh riskCholangitisPatientsTherapyLarger study
2019
Rates of Adverse IBD-Related Outcomes for Patients With IBD and Concomitant Prostate Cancer Treated With Radiation Therapy
Feagins LA, Kim J, Chandrakumaran A, Gandle C, Naik KH, Cipher DJ, Hou JK, Yao MD, Gaidos JKJ. Rates of Adverse IBD-Related Outcomes for Patients With IBD and Concomitant Prostate Cancer Treated With Radiation Therapy. Inflammatory Bowel Diseases 2019, 26: 728-733. PMID: 31412114, DOI: 10.1093/ibd/izz175.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFlare of IBDProstate cancerIBD patientsRadiation treatmentCancer diagnosisRadiation therapyRates of IBDInflammatory bowel disease flaresMultiple logistic regression analysisConcomitant prostate cancerVeterans Affairs hospital systemCharlson Comorbidity IndexRetrospective cohort studyRadiation-treated patientsExternal beam radiationBest treatment approachProstate cancer stageLogistic regression analysisProstate cancer diagnosisDisease flareIBD characteristicsComorbidity indexCohort studyBowel disease
2017
Sexuality, Fertility, and Pregnancy in Crohn's Disease
Gaidos J, Kane S. Sexuality, Fertility, and Pregnancy in Crohn's Disease. Gastroenterology Clinics Of North America 2017, 46: 531-546. PMID: 28838413, DOI: 10.1016/j.gtc.2017.05.007.Peer-Reviewed Original ResearchMeSH KeywordsCongenital AbnormalitiesCrohn DiseaseFemaleFertilityHumansImmunosuppressive AgentsInfant, Low Birth WeightInfant, Small for Gestational AgeInfertility, FemaleInfertility, MaleMaleMethotrexatePregnancyPregnancy ComplicationsPremature BirthRisk FactorsSexual HealthStillbirthTumor Necrosis Factor-alphaConceptsCrohn's diseaseAnti-tumor necrosis factor medicationsAdverse pregnancy outcomesInflammatory bowel diseaseActive diseaseQuiescent diseaseMedication regimenPregnancy outcomesBowel diseaseIntrauterine exposureGeneral populationLive vaccineSexual healthDrug concentrationsDiseasePregnancyMonthsOutcomesFertility rateRemissionMedicationsRegimenPatientsInfantsVaccineIncidence of and Predictors for Early Discontinuation of Biological Therapies in Veteran Patients with Inflammatory Bowel Disease
Feagins LA, Waljee A, Hou JK, Gu P, Kanjo S, Rudrapatna V, Cipher DJ, Govani S, Gaidos J. Incidence of and Predictors for Early Discontinuation of Biological Therapies in Veteran Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2017, 23: 1434-1439. PMID: 28570429, DOI: 10.1097/mib.0000000000001145.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBiological therapyAdverse drug reactionsConcomitant thiopurinesPrimary nonresponseEarly discontinuationBowel diseaseDrug reactionsDiagnosis of IBDBiological agentsFirst biological agentRetrospective cohort studyInitiation of therapyCourse of therapyVA hospital systemIleocolonic diseaseVA cohortCohort studyVeteran patientsMedical recordsRisk factorsCommon reasonPatientsDiscontinuationTherapy
2016
Timing of Last Preoperative Dose of Infliximab Does Not Increase Postoperative Complications in Inflammatory Bowel Disease Patients
Alsaleh A, Gaidos JK, Kang L, Kuemmerle JF. Timing of Last Preoperative Dose of Infliximab Does Not Increase Postoperative Complications in Inflammatory Bowel Disease Patients. Digestive Diseases And Sciences 2016, 61: 2602-2607. PMID: 27126205, PMCID: PMC4982818, DOI: 10.1007/s10620-016-4171-9.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAdolescentAdultAnastomotic LeakChildColitis, UlcerativeCrohn DiseaseDigestive System Surgical ProceduresFemaleGastrointestinal AgentsHumansIleusInflammatory Bowel DiseasesInfliximabIntestinal ObstructionMaleMiddle AgedPostoperative ComplicationsPreoperative CareReoperationRetrospective StudiesRisk FactorsSurgical Wound InfectionTime FactorsVenous ThromboembolismYoung AdultConceptsLast preoperative dosePostoperative complicationsInflammatory bowel diseasePreoperative doseLast doseUlcerative colitisCrohn's diseaseInflammatory bowel disease patientsMethodsRetrospective chart reviewBowel disease patientsResultsNo significant associationIBD patientsPreoperative statusChart reviewPreoperative useBackgroundThe associationBowel diseaseSurgeon typeSurgery typeSteroid useDisease patientsInfliximabComplicationsPatientsDisease type