2024
Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
Seo J, Gaddis N, Patchen B, Xu J, Barr R, O’Connor G, Manichaikul A, Gharib S, Dupuis J, North K, Cassano P, Hancock D. Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. American Journal Of Clinical Nutrition 2024, 119: 1227-1237. PMID: 38484975, PMCID: PMC11130669, DOI: 10.1016/j.ajcnut.2024.03.007.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide interactionsGWAS meta-analysesGenome-wide genotypingGenetic variant associationsPathway enrichment analysisGenetic architectureVariant associationsP38 MAPK pathwayAssociation studiesGene-environment interactionsBiological insightsGenetic variantsEnrichment analysisVariant signalsMeta-analyzed resultsMAPK pathwayBiological relevancePathwayForced vital capacityEvaluate interactive effectsMeta-analysesVariantsSmoking historyAssociated with FEV<sub>1</sub> an
2023
Eating disorders: are gut microbiota to blame?
Xu J, Carroll I, Huckins L. Eating disorders: are gut microbiota to blame? Trends In Molecular Medicine 2023, 30: 317-320. PMID: 38040602, PMCID: PMC11009075, DOI: 10.1016/j.molmed.2023.11.007.Peer-Reviewed Original Research
2022
Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: a phenome-wide and polygenic risk study
Xu J, Johnson JS, Signer R, Consortium E, Birgegård A, Jordan J, Kennedy MA, Landén M, Maguire SL, Martin NG, Mortensen PB, Petersen LV, Thornton LM, Bulik CM, Huckins LM. Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: a phenome-wide and polygenic risk study. The Lancet Digital Health 2022, 4: e604-e614. PMID: 35780037, PMCID: PMC9612590, DOI: 10.1016/s2589-7500(22)00099-1.Peer-Reviewed Original ResearchConceptsElectronic health recordsPolygenic risk scoresWeight trajectoriesDepression polygenic risk scoresObesity polygenic risk scoresHealth recordsWeight changeUK BiobankIndividual health statusLower disease riskGenetic associationPatient populationUS National InstitutesWeight managementStable weightRisk scoreHealthy populationHealth statusAnorexia nervosaBioMe BiobankDisease riskDisorder diagnosisMental healthWeight lossPhenome-wide association studyMapping anorexia nervosa genes to clinical phenotypes
Johnson J, Cote A, Dobbyn A, Sloofman L, Xu J, Cotter L, Charney A, Consortium E, Birgegård A, Jordan J, Kennedy M, Landén M, Maguire S, Martin N, Mortensen P, Thornton L, Bulik C, Huckins L. Mapping anorexia nervosa genes to clinical phenotypes. Psychological Medicine 2022, 53: 2619-2633. PMID: 35379376, PMCID: PMC10123844, DOI: 10.1017/s0033291721004554.Peer-Reviewed Original ResearchConceptsBody mass indexGenome-wide association studiesTranscriptome imputationElectronic health record phenotypingAssociation studiesPhenome-wide association studyS-PrediXcan analysisMeasurement of cholesterolTraditional genome-wide association studiesGenes associated with ANAssociation of genetic variantsSubstance useGenetically regulated gene expressionImpact of body mass indexConsequences of aberrant expressionBiobank cohortBiobank populationAssociated with measuresAssociation of ANGWAS findingsSecondary analysisS-PrediXcanDisease riskMass indexSignificant genesChange in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation
Xu J, Guertin K, Gaddis N, Agler A, Parker R, Feldman J, Kristal A, Arnold K, Goodman P, Tangen C, Hancock D, Cassano P. Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation. American Journal Of Clinical Nutrition 2022, 115: 1205-1216. PMID: 35040869, PMCID: PMC8970985, DOI: 10.1093/ajcn/nqac013.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Genotyping ArrayFunctional declineMixed-effects linear regressionAttenuate age-related declinePulmonary function declineFEV1 declineNever smokersFormer smokersAdherent participantsEuropean ancestryDietary intakeHigh dietary intakeEffect sizeCytochrome P450 family 4 subfamily F member 2SmokersGenotyping arraysAge-related declineLinear regressionAssociationC alleleMissense variantsT alleleMissense variationsPulmonary functionBaseline
2019
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association
Xu J, Gaddis N, Bartz T, Hou R, Manichaikul A, Pankratz N, Smith A, Sun F, Terzikhan N, Markunas C, Patchen B, Schu M, Beydoun M, Brusselle G, Eiriksdottir G, Zhou X, Wood A, Graff M, Harris T, Ikram M, Jacobs D, Launer L, Lemaitre R, O’Connor G, Oelsner E, Psaty B, Vasan R, Rohde R, Rich S, Rotter J, Seshadri S, Smith L, Tiemeier H, Tsai M, Uitterlinden A, Voruganti V, Xu H, Zilhão N, Fornage M, Zillikens M, London S, Barr R, Dupuis J, Gharib S, Gudnason V, Lahousse L, North K, Steffen L, Cassano P, Hancock D. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10–Pulmonary Function Association. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 631-642. PMID: 30199657, PMCID: PMC6396866, DOI: 10.1164/rccm.201802-0304oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Physiological PhenomenaSex FactorsSmokingVital CapacityConceptsSNP associationsGenome-wide interaction analysisHeart and Aging ResearchMeta-analysesCohort-specific resultsAssociated with lower FVCGenome-wide analysisGenomic Epidemiology ConsortiumAssociated with FEV<sub>1</sub> anPulmonary function testsEpidemiology ConsortiumFatty acidsEffect modificationFunctional associationN-3 PUFAPulmonary healthLower FVCGenetic susceptibilitySpirometric measurementsCohortPolyunsaturated fatty acidsAssociationMeasures of pulmonary function testsInteraction analysisFVC
2018
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
Xu J, Bartz T, Chittoor G, Eiriksdottir G, Manichaikul A, Sun F, Terzikhan N, Zhou X, Booth S, Brusselle G, de Boer I, Fornage M, Frazier-Wood A, Graff M, Gudnason V, Harris T, Hofman A, Hou R, Houston D, Jacobs D, Kritchevsky S, Latourelle J, Lemaitre R, Lutsey P, O’Connor G, Oelsner E, Pankow J, Psaty B, Rohde R, Rich S, Rotter J, Smith L, Stricker B, Voruganti V, Wang T, Zillikens M, Barr R, Dupuis J, Gharib S, Lahousse L, London S, North K, Smith A, Steffen L, Hancock D, Cassano P. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. British Journal Of Nutrition 2018, 120: 1159-1170. PMID: 30205856, PMCID: PMC6263170, DOI: 10.1017/s0007114518002180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlack or African AmericanBlack PeopleCross-Sectional StudiesFemaleForced Expiratory VolumeGenome, HumanHeartHeart DiseasesHumansLungLung DiseasesMaleMiddle AgedMolecular EpidemiologyProspective StudiesRegression AnalysisRespiratory Function TestsSmokingVital CapacityVitamin DWhite PeopleConceptsHeart and Aging ResearchForced vital capacityEuropean ancestryVitamin DNever smokersMeta-analysisAfrican ancestryHigher 25(OH)DPulmonary functionGenomic Epidemiology ConsortiumSerum 25-hydroxyvitamin DAssociation of serum vitamin DSerum vitamin DEpidemiology ConsortiumForced expiratory volumeEffect modificationFormer smokersSmoking statusSerum 25(OH)DVulnerable populationsAging researchSmokersEpidemiological studiesExpiratory volumeVital capacity