2018
Endothelial Cell Autonomous Role of Akt1
Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Endothelial Cell Autonomous Role of Akt1. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38: 870-879. PMID: 29449333, PMCID: PMC6503971, DOI: 10.1161/atvbaha.118.310748.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicBlood Flow VelocityBlood PressureDisease Models, AnimalEndothelial CellsHindlimbIschemiaMaleMice, KnockoutMuscle, SkeletalNeovascularization, PhysiologicNitric OxideNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktRegional Blood FlowSignal TransductionVasoconstriction
2014
Netrin-1 controls sympathetic arterial innervation
Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A. Netrin-1 controls sympathetic arterial innervation. Journal Of Clinical Investigation 2014, 124: 3230-3240. PMID: 24937433, PMCID: PMC4071369, DOI: 10.1172/jci75181.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornDCC ReceptorFemaleGrowth ConesMaleMesenteric ArteriesMiceMice, KnockoutMice, Mutant StrainsMice, TransgenicModels, NeurologicalMyocytes, Smooth MuscleNerve Growth FactorsNetrin-1PregnancyReceptors, Cell SurfaceSympathetic Nervous SystemTumor Suppressor ProteinsVasoconstrictionConceptsSmooth muscle cellsArterial innervationNetrin-1Resistance arteriesAutonomic sympathetic nervesArterial smooth muscle cellsPeripheral resistance arteriesBlood flow regulationOnset of innervationBlood flow controlCell type-specific deletionAxon guidance cue netrin-1Guidance cue netrin-1Sympathetic nervesSympathetic innervationVascular toneColorectal cancerPeripheral organsSympathetic neuronsBlood supplyInnervationMuscle cellsSympathetic growth conesArteryGrowth cones