Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer K, Siuciak J, Carson S, Radley H, Park J, Lewis D, Zlotchenko E, Nguyen T, Garcia K, Tonra J, Stambler N, Cedarbaum J, Bodine S, Lindsay R, Distefano P. Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat. Annals Of Neurology 1998, 43: 46-55. PMID: 9450768, DOI: 10.1002/ana.410430111.Peer-Reviewed Original ResearchConceptsLarge-fiber sensory neuropathySensory neuropathyGeneral healthSensory compound nerve action potentialMature ratsCompound nerve action potentialSensory conduction velocityForelimb grip strengthSevere axonal degenerationNerve action potentialsFrequency of dosingH-wave amplitudeAbility of ratsMotor amplitudeDosing schedulesPeripheral neuropathyAxonal degenerationDorsal rootsProprioceptive deficitsClinical syndromeMuscle strengthGrip strengthHeat nociceptionVentral rootsChemotherapeutic agent taxol