2023
VIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexDevelopmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
Batista-Brito R, Majumdar A, Nuño A, Ward C, Barnes C, Nikouei K, Vinck M, Cardin J. Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics. Molecular Psychiatry 2023, 28: 3133-3143. PMID: 37069344, PMCID: PMC10618960, DOI: 10.1038/s41380-023-02066-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsInterneuronsMiceNeuregulin-1NeuronsParvalbuminsPyramidal CellsReceptor, ErbB-4Signal TransductionConceptsPV interneuronsCortical neuronsCortical circuitsCortical circuit dynamicsCortical GABAergic cellsNRG1/ErbB4Excitatory cortical neuronsParvalbumin-Expressing InterneuronsInhibitory cortical neuronsApical dendritic tuftsActivity of excitatorySecond postnatal weekProper synaptic connectivityLate postnatal developmentState-dependent modulationLoss of ERBB4Excitatory componentGABAergic cellsGABAergic inhibitionSpine densityDendritic tuftsPostnatal weekNormal tuningSynaptic connectivityReceptor ErbB4Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity
Perrenoud Q, Cardin J. Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity. Neuron 2023, 111: 297-299. PMID: 36731427, DOI: 10.1016/j.neuron.2023.01.004.Peer-Reviewed Original Research
2022
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin J, Schnitzer M, Pieribone V. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types. Science 2022, 378: eabm8797. PMID: 36378956, PMCID: PMC9703638, DOI: 10.1126/science.abm8797.Peer-Reviewed Original Research
2018
Altered hippocampal interneuron activity precedes ictal onset
Miri ML, Vinck M, Pant R, Cardin J. Altered hippocampal interneuron activity precedes ictal onset. ELife 2018, 7: e40750. PMID: 30387711, PMCID: PMC6245730, DOI: 10.7554/elife.40750.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsElectroencephalographyHippocampusInterneuronsMiceOptogeneticsSeizuresConceptsSynaptic inhibitionIctal activityEarly ictal phaseHippocampal interneuron activityLocal circuit interactionsSomatostatin-expressing (SST) interneuronsInhibitory interneuron populationsSeizure inductionGABAergic inhibitionSeizure disorderIctal onsetSource of inhibitionSeizure initiationIctal phaseHippocampal circuitsInterneuron activityInterneuron populationsInterneuron classesFiring patternsInterneuronsElectrophysiological approachesPreictal periodInhibitionParvalbuminOnset
2011
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlén M, Meletis K, Siegle J, Cardin J, Futai K, Vierling-Claassen D, Rühlmann C, Jones S, Deisseroth K, Sheng M, Moore C, Tsai L. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry 2011, 17: 537-548. PMID: 21468034, PMCID: PMC3335079, DOI: 10.1038/mp.2011.31.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAssociation LearningBrain WavesConditioning, PsychologicalExcitatory Postsynaptic PotentialsGABA AntagonistsGABAergic NeuronsInterneuronsMaleMaze LearningMemory, Short-TermMiceMice, TransgenicParvalbuminsPhotic StimulationPicrotoxinReceptors, N-Methyl-D-AspartateSensory GatingStereotyped BehaviorConceptsGamma oscillationsSpecific cognitive behaviorSelective cognitive impairmentsGamma rhythmsPsychosis-like symptomsCognitive tasksAssociative learningNeural network dysfunctionCognitive behaviorCortical gamma rhythmsCognitive impairmentNetwork dysfunctionNMDAR neurotransmissionOptogenetic drivePV interneuronsParvalbumin interneuronsNMDAR antagonistsMemoryReduced sensitivityBehaviorTaskHabituationDeficitsNormal behaviorLearning
2010
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2
Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nature Protocols 2010, 5: 247-254. PMID: 20134425, PMCID: PMC3655719, DOI: 10.1038/nprot.2009.228.Peer-Reviewed Original ResearchConceptsOptical interferenceMajor long-term goalViral vectorsCell-type selectivityRecording of neuronsOptogenetic stimulationChannelrhodopsin-2Cre-dependent expressionBrain circuit functionSelective cell typesInhibitory interneuronsIntracellular recordingsVivo electrophysiologyExcitatory neuronsIntact brainType selectivityNeural subtypesOptogenetic techniquesSpecific populationsNeural activityCircuit functionNeuronsInterferenceCell typesStimulation
2009
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature 2009, 459: 663-667. PMID: 19396156, PMCID: PMC3655711, DOI: 10.1038/nature08002.Peer-Reviewed Original Research
2007
Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex
Cardin JA, Palmer LA, Contreras D. Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex. Journal Of Neuroscience 2007, 27: 10333-10344. PMID: 17898205, PMCID: PMC3025280, DOI: 10.1523/jneurosci.1692-07.2007.Peer-Reviewed Original ResearchConceptsPrimary visual cortexFS cellsVisual cortexRS cellsLayer 4Feature selectivityThalamorecipient layer 4Cortical sensory processingResponses of excitatorySynaptic responsesInhibitory neuronsSynaptic inputsSynaptic integrationInhibitory cellsMembrane potential fluctuationsStimulus selectivitySpike outputLow input resistanceFiring rateSpike tuningType-specific differencesInput resistanceSpiking cellsCell type-specific differencesRegular spiking