2022
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani S, Moberly A, Benisty H, Landa B, Jing M, Li Y, Higley M, Cardin J. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nature Neuroscience 2022, 25: 1706-1713. PMID: 36443609, PMCID: PMC10661869, DOI: 10.1038/s41593-022-01202-6.Peer-Reviewed Original ResearchConceptsCortical network activityBehavioral statesCholinergic modulationAnimal's behavioral stateCholinergic signalingAwake miceCortical functionFunctional reorganizationNeuromodulatory influencesDifferent motor behaviorsNeocortical activityAcetylcholineMotor behaviorCortical networksRecent evidenceBrain activityFunctional segregationNeocortexMesoscopic imagingHeterogeneous signalsNetwork activityBehavioral markersBehavioral variablesCircuit dynamicsCholinergic
2016
Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks
Lur G, Vinck MA, Tang L, Cardin JA, Higley MJ. Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks. Cell Reports 2016, 14: 2538-2545. PMID: 26972011, PMCID: PMC4805451, DOI: 10.1016/j.celrep.2016.02.050.Peer-Reviewed Original ResearchConceptsNeocortical sensory areasVisual response propertiesPrimary visual cortexVivo calcium imagingDownstream targetsCorticocortical cellsCorticostriatal cellsProjection neuronsRelevant downstream targetsCorticotectal cellsAfferent informationCortical subnetworksCC cellsVisual cortexCalcium imagingSensory areasSubcortical structuresLayer 5CT cellsDistinct subpopulationsSensory informationBroad tuningResponse propertiesCellsFunctional subnetworks