VIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexDevelopmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
Batista-Brito R, Majumdar A, Nuño A, Ward C, Barnes C, Nikouei K, Vinck M, Cardin J. Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics. Molecular Psychiatry 2023, 28: 3133-3143. PMID: 37069344, PMCID: PMC10618960, DOI: 10.1038/s41380-023-02066-3.Peer-Reviewed Original ResearchConceptsPV interneuronsCortical neuronsCortical circuitsCortical circuit dynamicsCortical GABAergic cellsNRG1/ErbB4Excitatory cortical neuronsParvalbumin-Expressing InterneuronsInhibitory cortical neuronsApical dendritic tuftsActivity of excitatorySecond postnatal weekProper synaptic connectivityLate postnatal developmentState-dependent modulationLoss of ERBB4Excitatory componentGABAergic cellsGABAergic inhibitionSpine densityDendritic tuftsPostnatal weekNormal tuningSynaptic connectivityReceptor ErbB4