Circuit Design Features of a Stable Two-Cell System
Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit Design Features of a Stable Two-Cell System. Cell 2018, 172: 744-757.e17. PMID: 29398113, PMCID: PMC7377352, DOI: 10.1016/j.cell.2018.01.015.Peer-Reviewed Original ResearchConceptsMost mammalian tissuesCell-cell contactGrowth factorNegative feedback regulationCell communicationMammalian tissuesCell survivalParacrine signalsFactor exchangeCell typesCell interactionsEnvironmental constraintsExperimental approachTwo-cell systemHomeostasisTissueRegulationCircuit design featuresCell circuitFibroblastsProliferationCellsAnalytical screeningEndocytosis as a stabilizing mechanism for tissue homeostasis
Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U. Endocytosis as a stabilizing mechanism for tissue homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e1926-e1935. PMID: 29429964, PMCID: PMC5828590, DOI: 10.1073/pnas.1714377115.Peer-Reviewed Original Research