2019
Validating the use of registries and claims data to support randomized trials: Rationale and design of the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data (EXTEND) Study
Strom JB, Tamez H, Zhao Y, Valsdottir LR, Curtis J, Brennan JM, Shen C, Popma JJ, Mauri L, Yeh RW. Validating the use of registries and claims data to support randomized trials: Rationale and design of the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data (EXTEND) Study. American Heart Journal 2019, 212: 64-71. PMID: 30953936, PMCID: PMC6535119, DOI: 10.1016/j.ahj.2019.02.007.Peer-Reviewed Original ResearchConceptsMedical therapyDual Antiplatelet Therapy StudyEnd pointEnd-point eventsClinical trial programEfficacy of therapyPatient-level dataClinical trial dataHealth system dataUse of registriesNew medical treatmentsProcedural registryRandomized trialsClaims databasePatient populationNational registryAdministrative claimsOutcome dataMedical treatmentTrial programTrial dataRegistryTrial informationTherapy studiesTrial results
2014
Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy
Wimmer NJ, Spertus JA, Kennedy KF, Anderson HV, Curtis JP, Weintraub WS, Singh M, Rumsfeld JS, Masoudi FA, Yeh RW. Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy. Journal Of The American Heart Association 2014, 3: e000728. PMID: 24938712, PMCID: PMC4309056, DOI: 10.1161/jaha.113.000728.Peer-Reviewed Original ResearchConceptsCarotid artery revascularizationCarotid endarterectomyHospital strokeHospital qualityArtery diseaseCEA scoreNew York Heart Association class IIIHospital risk-adjusted outcomesPrimary end-point eventPrior peripheral artery diseaseContralateral carotid occlusionHospital-level clusteringSymptomatic carotid lesionsPeripheral artery diseaseEnd-point eventsCoronary artery diseaseModerate discriminative abilityRisk-adjusted outcomesClinical prediction modelHierarchical logistic regressionArtery revascularizationEndarterectomy (CARE) RegistryAppropriate risk adjustmentCarotid occlusionDiabetes mellitus