2023
Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes
Yankee T, Oh S, Winchester E, Wilderman A, Robinson K, Gordon T, Rosenfeld J, VanOudenhove J, Scott D, Leslie E, Cotney J. Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes. Nature Communications 2023, 14: 4623. PMID: 37532691, PMCID: PMC10397224, DOI: 10.1038/s41467-023-40363-1.Peer-Reviewed Original ResearchConceptsGene co-expression analysisSingle-cell RNA-seqCraniofacial disordersSet of genesCo-expression analysisTranscriptome dynamicsDevelopmental enhancersRegulatory hubEpigenomic dataCraniofacial developmentRNA-seqDe novo mutationsDisease genesGene expressionIntegrative analysisCraniofacial tissuesGenesNovo mutationsHuman tissuesMutationsDevelopment identifiesCommon congenital defectsWeeks post conceptionPost conceptionCraniofacial region
2016
MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells
Browne G, Dragon J, Hong D, Messier T, Gordon J, Farina N, Boyd J, VanOudenhove J, Perez A, Zaidi S, Stein J, Stein G, Lian J. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumor Biology 2016, 37: 8825-8839. PMID: 26749280, PMCID: PMC4939137, DOI: 10.1007/s13277-015-4710-6.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsBreast cancer progressionMiR-378Breast cancer cellsCancer progressionMMTV-PyMT transgenic mouse modelCancer cellsLuciferase reporter assaysMiRNA replacement therapyMDA-MB-231 human breast cancer cellsBreast cancerTranscription factorsNumerous miRNAsEctopic expressionRegulatory pathwaysUntranslated regionMicroarray profilingReporter assaysHuman breast cancer cellsTriple-negative MDA-MB-231Breast cancer cell line MCF7Human breast cancer cell line MCF7Cell migrationRUNX1 expressionNormal hematopoiesis