2016
HIV Drug Resistance Mutations (DRMs) Detected by Deep Sequencing in Virologic Failure Subjects on Therapy from Hunan Province, China
Chen X, Zou X, He J, Zheng J, Chiarella J, Kozal MJ. HIV Drug Resistance Mutations (DRMs) Detected by Deep Sequencing in Virologic Failure Subjects on Therapy from Hunan Province, China. PLOS ONE 2016, 11: e0149215. PMID: 26895182, PMCID: PMC4760947, DOI: 10.1371/journal.pone.0149215.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsVirologic failureDetection of DRMsPrevalence of DRMsSanger sequencingHIV drug resistance mutationsResistance mutationsART-experienced patientsART-experienced subjectsTreatment-experienced subjectsMedian viral loadNNRTI resistance mutationsStandard genotypingART adherenceViral loadAE subtypeMutation prevalenceDeep sequencingFailure subjectsExperienced subjectsResistant variantsOnly variablePatientsPrevalenceSubtypes
2014
Prevalence of WHO Transmitted Drug Resistance Mutations by Deep Sequencing in Antiretroviral-Naïve Subjects in Hunan Province, China
Xiaobai Z, Xi C, Tian H, Williams AB, Wang H, He J, Zhen J, Chiarella J, Blake LA, Turenchalk G, Kozal MJ. Prevalence of WHO Transmitted Drug Resistance Mutations by Deep Sequencing in Antiretroviral-Naïve Subjects in Hunan Province, China. PLOS ONE 2014, 9: e98740. PMID: 24896087, PMCID: PMC4045886, DOI: 10.1371/journal.pone.0098740.Peer-Reviewed Original ResearchConceptsART-naïve subjectsFirst-line antiretroviral therapyLine Antiretroviral TherapyPI TDRsDrug resistance mutationsNNRTI TDRAntiretroviral therapyPI mutationsPI/r useTransmitted Drug Resistance MutationsResistance mutationsAntiretroviral-naïve subjectsAdvanced chronic diseaseHigh-level resistanceAdvanced diseaseNNRTI mutationsNevirapine resistanceNRTI resistanceHIV variantsTime of testingChronic diseasesAE subtypeTreatment responseSubtype AER use
2009
Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use
Le T, Chiarella J, Simen BB, Hanczaruk B, Egholm M, Landry ML, Dieckhaus K, Rosen MI, Kozal MJ. Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use. PLOS ONE 2009, 4: e6079. PMID: 19562031, PMCID: PMC2698118, DOI: 10.1371/journal.pone.0006079.Peer-Reviewed Original ResearchConceptsAntiretroviral treatment historyDrug-resistant mutationsVirologic failureAntiretroviral useDrug-resistant variantsTreatment historyOverall burdenGenotypic resistanceHIV drug-resistant mutationsHIV drug-resistant variantsStanford HIV database algorithmDrug-resistant viral variantsSubsequent antiretroviral regimensTreatment-experienced patientsConventional genotypingPrior treatment historyUltra-deep pyrosequencingSanger sequencingAntiretroviral regimensMore antiretroviralsChart reviewAntiretroviral drugsUltra-deep sequencingClinical implicationsViral variants
2004
Antiretroviral resistance and high-risk transmission behavior among HIV-positive patients in clinical care
Kozal MJ, Amico KR, Chiarella J, Schreibman T, Cornman D, Fisher W, Fisher J, Friedland G. Antiretroviral resistance and high-risk transmission behavior among HIV-positive patients in clinical care. AIDS 2004, 18: 2185-2189. PMID: 15577652, DOI: 10.1097/00002030-200411050-00011.Peer-Reviewed Original ResearchConceptsHIV-positive patientsTransmission risk behaviorsHIV transmission risk behaviorsViral loadUnprotected sexual eventsRisk behaviorsAntiretroviral therapyCopies/Clinical careHIV sexual transmission risk behaviorsUnprotected sexHigh-risk transmission behaviorsSexual transmission risk behaviorLower mental health scoresHIV transmission eventsUndetectable viral loadProportion of patientsHIV drug resistanceDrug-resistant HIVMental health scoresCross-sectional studyHIV transmission behaviorsDrug resistance dataAntiretroviral resistanceResistant HIV