Featured Publications
Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage
Zheng WL, Kim JA, Elmer J, Zafar SF, Ghanta M, Moura V, Patel A, Rosenthal E, Westover M. Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2022, 143: 97-106. PMID: 36182752, PMCID: PMC9847346, DOI: 10.1016/j.clinph.2022.08.023.Peer-Reviewed Original ResearchConceptsMultiple EEG featuresEEG featuresInformative featuresPrediction algorithmSubarachnoid hemorrhageBetter performanceNon-DCI patientsMachineCerebral ischemiaDCI riskAlpha-delta ratioAneurysmal subarachnoid hemorrhageUtility of electroencephalographyReceiver operator curveFeaturesDCI predictionAlgorithmDCI onsetSAH patientsShannon entropyDay 5Whole brainAlpha variabilityPatientsPredictionHigh epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage
Kim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2021, 141: 139-146. PMID: 33812771, PMCID: PMC8429508, DOI: 10.1016/j.clinph.2021.01.022.Peer-Reviewed Original ResearchConceptsED burdenSubarachnoid hemorrhageEpileptiform dischargesCerebral ischemiaSAH patientsHigh riskOnset of DCIMajor risk periodContinuous EEG recordingsDCI patientsDCI riskRetrospective analysisNovel biomarkersGroup-based trajectory analysisRisk periodPatientsDay 3.5DCIBurdenHemorrhageIschemiaRiskEEG recordingsBurden rateUseful parameter
2021
Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage
Lissak IA, Locascio JJ, Zafar SF, Schleicher RL, Patel AB, Leslie-Mazwi T, Stapleton CJ, Koch MJ, Kim JA, Anderson K, Rosand J, Westover MB, Kimberly WT, Rosenthal ES. Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage. Neurocritical Care 2021, 35: 397-408. PMID: 33483913, PMCID: PMC7822587, DOI: 10.1007/s12028-020-01177-x.Peer-Reviewed Original ResearchConceptsHospital-acquired infectionsHospital complicationsEpileptiform abnormalitiesSubarachnoid hemorrhageCerebral ischemiaLongitudinal outcomesContinuous EEGNon-traumatic subarachnoid hemorrhageTime pointsNontraumatic subarachnoid hemorrhageEffects modelCumulative proportional odds modelRankin ScaleProspective studyFunctional outcomeResultsIn totalBaseline severityCEEG monitoringTherapeutic targetComplicationsSustained impairmentMRS assessmentSecondary analysisLongitudinal assessmentMixed effects models
2020
Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage
Lissak IA, Zafar SF, Westover MB, Schleicher RL, Kim JA, Leslie-Mazwi T, Stapleton CJ, Patel AB, Kimberly WT, Rosenthal ES. Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage. Stroke 2020, 51: 1128-1134. PMID: 32156203, PMCID: PMC7123848, DOI: 10.1161/strokeaha.119.028515.Peer-Reviewed Original ResearchConceptsPlasma sST2 levelsSoluble ST2Epileptiform abnormalitiesNontraumatic subarachnoid hemorrhageSubarachnoid hemorrhageSST2 levelsNeurophysiologic changesCerebral ischemiaIL-6Continuous electroencephalographyMeasures mixed-effects modelsInnate immune response pathwaysAdmission risk factorsPlasma soluble ST2Secondary brain injurySubgroup of patientsSubarachnoid hemorrhage patientsSerial plasma samplesAssociation of biomarkersInnate immune responseWilcoxon rank sum testImmune response pathwaysMixed-effects modelingRank sum testInflammatory biomarkers
2017
Epileptiform abnormalities predict delayed cerebral ischemia in subarachnoid hemorrhage
Kim JA, Rosenthal ES, Biswal S, Zafar S, Shenoy AV, O'Connor KL, Bechek SC, Moura J, Shafi MM, Patel AB, Cash SS, Westover MB. Epileptiform abnormalities predict delayed cerebral ischemia in subarachnoid hemorrhage. Clinical Neurophysiology 2017, 128: 1091-1099. PMID: 28258936, PMCID: PMC5476529, DOI: 10.1016/j.clinph.2017.01.016.Peer-Reviewed Original ResearchConceptsCerebral ischemiaSubarachnoid hemorrhageRisk of DCISecondary cerebral injuryRhythmic delta activityAbnormal neural activityNew potential targetsCerebral injuryEarly patientsEpileptiform abnormalitiesMedical recordsEpileptiform dischargesRetrospective analysisHigh riskDCI developmentDelta activityPatientsNovel markerIschemiaSurvival analysis methodsCumulative probabilityPotential targetNeural activityNew markersDCI